1-METHYL-5-NITRO-ISATIN Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

1-METHYL-5-NITRO-ISATIN Usage And Synthesis

Preparation

A mixture of nitroisatin 31 (10 g, 0.052 mol), MeI (16.21 ml, 0.260  mol) and K2CO3 (21.56 g, 1.56 mol) in anhydrous DMF was stirred  overnight at room temperature. Water was added to the reaction  mixture and acidified with dilute HCl till acidic to pH paper. A  yellow solid separated, 1-Methyl-5-nitroisatin was filtered and washed thoroughly  with water till neutral to pH paper and air dried to a constant weight (9.66 g).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 39, p. 5072, 1996 DOI: 10.1021/jm960603e

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