5-Nitroisatin Chemical Properties

Melting point:

251 °C (dec.) (lit.)

Boiling point:

328.09°C (rough estimate)

Density 

1.5513 (rough estimate)

refractive index 

1.4900 (estimate)

storage temp. 

Sealed in dry,Room Temperature

pka

8.06±0.20(Predicted)

form 

Crystalline Powder

color 

Orange-yellow to orange

BRN 

180223

InChIKey

UNMYHYODJHKLOC-UHFFFAOYSA-N

CAS DataBase Reference

611-09-6(CAS DataBase Reference)

NIST Chemistry Reference

1H-indole-2,3-dione, 5-nitro-(611-09-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-40-68-22

Safety Statements 

7-22-36/37/39-45-36/37

RIDADR 

2811

WGK Germany 

3

RTECS 

NL7970000

HazardClass 

IRRITANT

HS Code 

29337900

MSDS

• Language:English Provider:5-Nitroisatin
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Nitroisatin Usage And Synthesis

Preparation

Isatin 30 (14.7 g, 0.1 mol) was added to conc. H2SO4 (121 ml)  cooled to 0 ºC in an ice-salt bath. Fuming HNO3 (4.2 ml) was  added to this, drop by drop, in such a way that temperature should  not rise above 5 ºC. The reaction mixture was allowed to stand for  about 30 minutes and then poured over crushed ice (500 g). A yellow precipitate separated  immediately. The 5-Nitroisatin was filtered and washed with water and air dried to a constant  weight (15 g).  Yield : 85%

Chemical Properties

orange-yellow to orange crystalline powder

Uses

Reactant for preparation of:

• Potential antibacterial and antifungal agents
• spiro[indole-thiazolidinones] as a medicinally important scaffold
• Potential antimycobacterial agents
• Anticonvulsant agents
• Inhibitors of human transglutaminase 2
• Anthelmintic agents
• Anti-human immunodeficiency virus (HIV) agents
• Antimicrobial agents
• Potential antitubercular agents
• Inhibitors of acetylcholinesterase

Definition

ChEBI: 5-Nitroisatin is a member of indoles. It has a role as an anticoronaviral agent.

5-Nitroisatin(611-09-6)Related Product Information

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