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Oxindole

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Oxindole Basic information

Product Name:
Oxindole
Synonyms:
  • OXINDOL
  • OXINDOLE
  • O-(AMINOPHENYL)ACETIC ACID LACTAM
  • TIMTEC-BB SBB004215
  • 2-Oxo-2,3-dihydroindole
  • Indoline-2-one
  • NSC 274863
  • 1,3-dihydro-2h-indol-2-on
CAS:
59-48-3
MF:
C8H7NO
MW:
133.15
EINECS:
200-429-5
Product Categories:
  • Aromatic Phenylacetic Acids and Derivatives
  • Indoles and derivatives
  • blocks
  • IndolesOxindoles
  • Indoline & Oxindole
  • Heterocycle-Indole series
  • Indoles
  • Indole Derivatives
Mol File:
59-48-3.mol
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Oxindole Chemical Properties

Melting point:
123-128 °C(lit.)
Boiling point:
227 °C73 mm Hg(lit.)
Density 
1.1475 (rough estimate)
refractive index 
1.5282 (estimate)
Flash point:
194-196°C/17mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
9.1g/l
pka
14.77±0.20(Predicted)
form 
Solid
color 
Light Brown
Water Solubility 
insoluble
BRN 
114692
CAS DataBase Reference
59-48-3(CAS DataBase Reference)
NIST Chemistry Reference
2H-Indol-2-one, 1,3-dihydro-(59-48-3)
EPA Substance Registry System
Oxindol (59-48-3)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
NM2080500
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29337900

MSDS

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Oxindole Usage And Synthesis

Chemical Properties

beige to yellowish-orange or pinkish-brown powder

Uses

Oxindole is considered as indole analogue, which shows pharmacological activity.

Uses

Indole analogue; shows pharmacological activity

Definition

ChEBI: Indolin-2-one is an indolinone carrying an oxo group at position 2. It is an indolinone and a gamma-lactam.

Hazard

Causes flaccid paralysis without anesthesia (usually neuromuscular blockage), changes in motor activity, and ataxia in oral and intraperitoneal lethal-dose studies of mice;  May cause irritation; Harmful by ingestion.

Solubility in organics

Oxindole is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of oxindole in ethanol and DMF is approximately 10 mg/ml and approximately 3 mg/ml in DMSO. Oxindole is sparingly soluble in aqueous buffers.

Oxindole Preparation Products And Raw materials

Preparation Products

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