- Product Name:
- Product Categories:
- Oxygen cyclic compounds
- Carbonyl Compounds
- Pyrans, Piperidines &Piperazines
- Pyrans, Piperidines & Piperazines
- Heterocycles series
- Heterocycle-other series
- Mol File:
Tetrahydro-4H-pyran-4-one Chemical Properties
- Boiling point:
- 166-166.5 °C (lit.)
- 1.084 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.452(lit.)
- Flash point:
- 134 °F
- storage temp.
- Keep Cold
- Clear colorless to pale yellow
- Water Solubility
- CAS DataBase Reference
- 29943-42-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 4H-Pyran-4-one, tetrahydro-(29943-42-8)
Tetrahydro-4H-pyran-4-one Usage And Synthesis
Tetrahydro-4-pyrone is used in organic synthesis as a building block for more complex chemical structures because it participates in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid and it undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of penicillins and in a ring of vitamin D3. Additionally, tetrahydro-4-pyrone is used as solvents in some reactions.
Tetrahydro-4H-pyran-4-one is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes.
The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. Tetrahydro-4H-pyran-4-one is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3.
colorless to light yellow liquid
Tetrahydro-4-pyrone is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions.
Purify the pyrone by repeated distillation, preferably in a vacuum. [Baker J Chem Soc 296 1944, IR: Olsen & Bredoch Chem Ber 91 1589 1958.] The oxime has m 87-88o and b 110-111o/13mm [Cornubert et al. Bull Soc Chim Fr 36 1950]. The 4-nitrophenylhydrazone forms orange-brown needles from EtOH, m 186o [Cawley & Plant J Chem Soc 1214 1938]. [Beilstein 17 I 131, 17 II 287, 17 III/IV 4171, 17/9 V 21.]
Tetrahydro-4H-pyran-4-one Preparation Products And Raw materials
- 5-Formylsalicylic acid
- TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE
- Tetrahydro-2H-pyran-4-carboxylic acid
- Tetrahydropyranyl-4-acetic acid
- Ethyl Tetrahydropyran-4-Carboxylate
- ETHYL TETRAHYDROPYRAN-4-YL-ACETATE