Tetrahydropyran-4-carbaldehyde Chemical Properties

Boiling point:

74-77 °C(Press: 11 Torr)

Density 

1.096±0.06 g/cm3(Predicted)

Flash point:

>23℃

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

liquid

color 

Almost colourless

InChI

InChI=1S/C6H10O2/c7-5-6-1-3-8-4-2-6/h5-6H,1-4H2

InChIKey

CXLGNJCMPWUZKM-UHFFFAOYSA-N

SMILES

C1OCCC(C=O)C1

CAS DataBase Reference

50675-18-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-20/21/22

Safety Statements 

26-36/37-24/25

RIDADR 

1993

Hazard Note 

Irritant/Keep Cold

HS Code 

29339900

Tetrahydropyran-4-carbaldehyde Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

4-Formyltetrahydropyran is used in preparation of the heterocyclic compounds and their medical applications.

Synthesis

General procedure for the synthesis of tetrahydropyran-4-carbaldehyde from 4-cyanotetrahydropyran: Referring to Example 2. To a solution of toluene (10 mL) containing tetrahydropyran-4-carbonitrile (1.0 g, 9.0 mmol) was slowly added, at -78° C., a solution of diisobutylaluminum hydride (DIBAL-H, 10.8 mL, 10.8 mmol, 1.0 M of the toluene solution ). The reaction mixture was stirred continuously at -78 °C for 1 h, followed by slow warming to room temperature. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product tetrahydropyran-4-carbaldehyde (530 mg, 52% yield).

References

[1] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 110

Tetrahydropyran-4-carbaldehyde(50675-18-8)Related Product Information

• Tetrahydro-2H-pyran-4-carboxylic acid
• Tetrahydro-4H-pyran-4-one
• Tetrahydropyran
• Centchroman
• Tetramethylammonium hydroxide pentahydrate
• Tetrahydrofuran
• TRI-TERT-BUTYLPHOSPHONIUM TETRAPHENYLBORATE
• Tetracyanoethylene
• (TETRAHYDRO-FURAN-3-YL)-ACETIC ACID
• TETRAHYDROPYRAN-4-BORONIC ACID
• (S)-TETRAHYDRO-2H-PYRAN-3-OL
• Tetrahydropyran-4-SulfonylChloride
• 1,1-Dioxo-tetrahydro-thiopyran-4-one
• Tetrahydrothiopyran-4-one
• Methyl tetrahydropyran-4-carboxylate
• ETHYL TETRAHYDROPYRAN-4-YL-ACETATE
• Ethyl Tetrahydropyran-4-Carboxylate
• 2-(TETRAHYDRO-2H-PYRAN-4-YL)ACETAMIDE