5-Bromo-1,2,3-trifluorobenzene Chemical Properties

Melting point:

<-20°C

Boiling point:

47-49 °C60 mm Hg(lit.)

Density 

1.767 g/mL at 25 °C(lit.)

vapor pressure 

8.65hPa at 25℃

refractive index 

n20/D 1.482(lit.)

Flash point:

113 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.130g/l

form 

clear liquid

Specific Gravity

1.78

color 

Colorless to Almost colorless

Water Solubility 

insoluble

BRN 

7249191

InChIKey

HKJCELUUIFFSIN-UHFFFAOYSA-N

LogP

3.53 at 40℃

CAS DataBase Reference

138526-69-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N,Xi,F

Risk Statements 

10-38-40-41-51/53-36/37/38

Safety Statements 

23-26-36/37/39-61-36-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

2

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29036990

MSDS

• Language:English Provider:5-Bromo-1,2,3-trifluorobenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Bromo-1,2,3-trifluorobenzene Usage And Synthesis

Chemical Properties

Clear slightly yellow liquid

Uses

5-Bromo-1,2,3-trifluorobenzene was used in flow preparation of 4,4,5,5-tetramethyl-2-(3,4,5-trifluorophenyl)-1,3,2-dioxaborolane.

Uses

Intermediates of Liquid Crystals

Flammability and Explosibility

Flammable

Synthesis

3,4,5-trifluorobromobenzene was synthesized as follows: (1) 1 mole of 1,2,3-trifluorobenzene and 3 moles of methylene chloride were added to a 2-liter reaction flask, and the mixed solution was cooled to 8-12°C; (2) 1.0 mole of sodium bromide and 120 g of sodium dihydrogen phosphate were dissolved in water to prepare an aqueous solution, which was cooled to 12°C and then added to the reaction flask of step (1); (3) at 15°C, a 10% sodium hypochlorite solution containing 1.2 moles of sodium hypochlorite was slowly added dropwise to the reaction flask, and the dropwise process lasted for 100 minutes, and then the reaction was continued at the same temperature for 60 minutes; (4) after completion of the reaction, the reaction was static layered, and the organic phase was separated, washed with water to neutrality, and dried with calcium chloride, and then the solvent was removed, and the crude 3,4,5-trifluorobromobenzene was obtained; (5) the crude product was at -25 °C Melt recrystallization was carried out to obtain 200 g of pure 3,4,5-trifluorobromobenzene with a yield of 94.6% and a purity of 99.5%.

References

[1] Patent: CN108947763, 2018, A. Location in patent: Paragraph 0020-0040
[2] European Journal of Organic Chemistry, 2003, # 3, p. 447 - 451
[3] European Journal of Organic Chemistry, 2003, # 3, p. 447 - 451
[4] European Journal of Organic Chemistry, 2003, # 3, p. 447 - 451
[5] European Journal of Organic Chemistry, 2003, # 3, p. 447 - 451

5-Bromo-1,2,3-trifluorobenzene(138526-69-9)Related Product Information

• 3,4,5-Trifluorobenzylamine
• 3,4,5-TRICHLOROPYRIDAZINE
• 1-Bromo-2,3,5-trifluorobenzene98%,1-Bromo-2,3,5-trifluorobenzene 98%,1-BROMO-2,3,5-TRIFLUOROBENZENE
• 1-Bromo-2,4,6-trifluorobenzene
• 2-BROMO-3,4,5,6-TETRAFLUOROBENZOTRIFLUORIDE
• 5-Bromo-1,2,3-trifluorobenzene
• 2-BROMO-3,4,5,6-TETRAFLUOROBENZYLALCOHOL
• 2-BROMO-4,5,6-TRIFLUOROANILINE
• 2-BROMO-3,4,5,6-TETRAFLUOROBENZOYL CHLORIDE
• 2-Bromo-3,4,5,6-tetrafluorotoluene
• 2-Bromo-3,4,5,6-tetrafluorobenzoic acid
• 1,2-Dibromotetrafluorobenzene
• 1-BROMO-2,3,4,5-TETRAFLUOROBENZENE
• Bromopentafluorobenzene
• 2,3,4-Trifluorobromobenzene
• 1-Bromo-2,4,5-trifluorobenzene
• 2-BROMO-1,3,4-TRIFLUOROBENZENE,1-Bromo-2,3,6-trifluorobenzene 98%,1-Bromo-2,3,6-trifluorobenzene98%
• Bromobenzene