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GALANTHAMINE HYDROBROMIDE

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GALANTHAMINE HYDROBROMIDE Basic information

Product Name:
GALANTHAMINE HYDROBROMIDE
Synonyms:
  • 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benza
  • 3,2-efg)(2)benzazocin-6-ol,1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-benzofuro(
  • galanthaminehydrogenbromide
  • jilkonhydrobromide
  • lycoreminehydrobromide
  • 5-Methoxy-9-methyl-2,3,3a,3a1,8,9,10,11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide
  • GALANTHAMINE HBR
  • GALANTAMINE HBR
CAS:
69353-21-5
MF:
C17H22BrNO3
MW:
368.27
EINECS:
217-780-5
Product Categories:
  • Galantamine
Mol File:
69353-21-5.mol
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GALANTHAMINE HYDROBROMIDE Chemical Properties

storage temp. 
Sealed in dry,Room Temperature
form 
White solid
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DF8075000
HazardClass 
6.1(b)
PackingGroup 
III

MSDS

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GALANTHAMINE HYDROBROMIDE Usage And Synthesis

General Description

A competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models.

Biochem/physiol Actions

Primary TargetAcetylcholinesterase

Clinical Use

Galantamine, which was introduced in 2001, is an alkaloid found in plants of the family Amaryllidaceae, which includes the daffodil (Narcissus pseudonarcissus) and snowflake (Leucojum aestivum). It is a reversible inhibitor of AChE, but it does not appear to inhibit butyrylcholinesterase. Because it is a tertiary amine and can cross the blood-brain barrier, it is indicated for treatment of mild-to-moderate AD and dementia. It has been used outside the U.S. for more than 30 years as an anticurare agent in anesthesia. Galantamine differs from other cholinesterase inhibitors, because it allosterically binds to nicotinic receptors, giving it a dual cholinergic action.

Metabolism

It is metabolized (75%) by CYP2D6 and CYP3A4 to afford the normethyl, O-desmethyl, and O-desmethylnormethyl metabolites, along with some other minor metabolites. Unlike tacrine, galantamine is not associated with hepatotoxicity. Its elimination half-life is 5.7 hours.

GALANTHAMINE HYDROBROMIDESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Aktin Chemicals, Inc.
Tel
86-28-85159085
Email
info@aktinchem.com
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