Cholinergic drugs
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The drugs which have similar role as acetylcholine are collectively referred to cholinergic drugs. According to its role in different principles, they can be divided into cholinergic like receptor agonists and cholinesterase inhibitors.
Choline receptor agonists can directly bind to the cholinergic receptor, resulting in a similar effect to acetylcholine.
Acetylcholine is a cholinergic neurotransmitter that activates the M-cholinergic receptor and the N-cholinergic receptor. When the M receptor is agitated, its effect often manifest as heart suppression, vasodilation, visceral smooth muscle contraction, sphincter relaxation and increased glandular secretion. These effects are called M-like effect. When the N receptor is agitated, its effect often manifest as ganglion excitement, skeletal muscle contraction and these effects are called N-like effect.
Because of the instability of chemical nature of acetylcholine in human body, it could quickly loose its effect by cholinesterase hydrolysis. It has been used widely so there is not a high selectivity. So it has no clinical value. Some compounds which has the similar chemical structure as acetylcholine are more stable and has high selectivity. So they has wide clinical applications.
Choline receptor agonists can directly bind to the cholinergic receptor, resulting in a similar effect to acetylcholine.
Acetylcholine is a cholinergic neurotransmitter that activates the M-cholinergic receptor and the N-cholinergic receptor. When the M receptor is agitated, its effect often manifest as heart suppression, vasodilation, visceral smooth muscle contraction, sphincter relaxation and increased glandular secretion. These effects are called M-like effect. When the N receptor is agitated, its effect often manifest as ganglion excitement, skeletal muscle contraction and these effects are called N-like effect.
Because of the instability of chemical nature of acetylcholine in human body, it could quickly loose its effect by cholinesterase hydrolysis. It has been used widely so there is not a high selectivity. So it has no clinical value. Some compounds which has the similar chemical structure as acetylcholine are more stable and has high selectivity. So they has wide clinical applications.
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- Structure:
- Chemical Name:
- Naphazoline hydrochloride
- CAS:
- 550-99-2
- MF:
- C14H14N2.ClH
- Structure:
- Chemical Name:
- Choline chloride
- CAS:
- 67-48-1
- MF:
- C5H14ClNO
- Structure:
- Chemical Name:
- Atropine sulfate monohydrate
- CAS:
- 5908-99-6
- MF:
- C17H25NO7S
- Structure:
- Chemical Name:
- Choline bitartrate
- CAS:
- 87-67-2
- MF:
- C9H19NO7
- Structure:
- Chemical Name:
- Galantamine Hydrobromide
- CAS:
- 1953-04-4
- MF:
- C17H22BrNO3
- Structure:
- Chemical Name:
- (-)-Huperzine A
- CAS:
- 102518-79-6
- MF:
- C15H18N2O
- Structure:
- Chemical Name:
- Acetylcholine chloride
- CAS:
- 60-31-1
- MF:
- C7H16ClNO2
- Structure:
- Chemical Name:
- Scopolamine hydrobromide
- CAS:
- 114-49-8
- MF:
- C17H21NO4.BrH
- Structure:
- Chemical Name:
- Choline glycerophosphate
- CAS:
- 28319-77-9
- MF:
- C8H20NO6P
- Structure:
- Chemical Name:
- Neostigmine Methyl Sulfate
- CAS:
- 51-60-5
- MF:
- C12H19N2O2.CH3O4S
- Structure:
- Chemical Name:
- PHYSOSTIGMINE
- CAS:
- 57-47-6
- MF:
- C15H21N3O2
- Structure:
- Chemical Name:
- Neostigmine bromide
- CAS:
- 114-80-7
- MF:
- C12H19BrN2O2
- Structure:
- Chemical Name:
- METHACHOLINE CHLORIDE
- CAS:
- 62-51-1
- MF:
- C8H18ClNO2
- Structure:
- Chemical Name:
- Choline hydroxide
- CAS:
- 123-41-1
- MF:
- C5H15NO2
- Structure:
- Chemical Name:
- HOMATROPINE METHYL BROMIDE
- CAS:
- 80-49-9
- MF:
- C17H24BrNO3
- Structure:
- Chemical Name:
- Mestinon
- CAS:
- 101-26-8
- MF:
- C9H13BrN2O2
- Structure:
- Chemical Name:
- PHYSOSTIGMINE SALICYLATE
- CAS:
- 57-64-7
- MF:
- C22H27N3O5
- Structure:
- Chemical Name:
- Atropine
- CAS:
- 51-55-8
- MF:
- C17H23NO3
- Structure:
- Chemical Name:
- ANISODINE
- MF:
- C17H21NO5
- Structure:
- Chemical Name:
- Huperzine A
- CAS:
- 120786-18-7
- MF:
- C15H18N2O
- Structure:
- Chemical Name:
- Acetylcholine
- CAS:
- 51-84-3
- MF:
- C7H16NO2+
- Structure:
- Chemical Name:
- CHOLINE
- CAS:
- 62-49-7
- MF:
- C5H14NO+
- Structure:
- Chemical Name:
- Homatropine Hydrobromide
- CAS:
- 51-56-9
- MF:
- C16H22BrNO3
- Structure:
- Chemical Name:
- 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
- CAS:
- 522-48-5
- MF:
- C13H17ClN2
- Structure:
- Chemical Name:
- Carbachol
- CAS:
- 51-83-2
- MF:
- C6H15N2O2.Cl
- Structure:
- Chemical Name:
- PILOCARPINE
- CAS:
- 92-13-7
- MF:
- C11H16N2O2
- Structure:
- Chemical Name:
- Naphazoline
- CAS:
- 835-31-4
- MF:
- C14H14N2
- Structure:
- Chemical Name:
- Pilocarpine nitrate
- CAS:
- 148-72-1
- MF:
- C11H17N3O5
- Structure:
- Chemical Name:
- GALANTHAMINONE
- CAS:
- 510-77-0
- MF:
- C17H19NO3
- Structure:
- Chemical Name:
- ambenonium chloride
- CAS:
- 115-79-7
- MF:
- C28H42Cl2N4O2.2Cl
- Structure:
- Chemical Name:
- GALANTHAMINE HYDROBROMIDE
- CAS:
- 69353-21-5
- MF:
- C17H22BrNO3
- Structure:
- Chemical Name:
- Tetryzoline
- CAS:
- 84-22-0
- MF:
- C13H16N2
- Structure:
- Chemical Name:
- BENZETIMIDE
- CAS:
- 21888-98-2
- MF:
- C23H26N2O2
- Structure:
- Chemical Name:
- Anisodamine
- CAS:
- 17659-49-3
- MF:
- C17H23NO4
- Structure:
- Chemical Name:
- Demecarium bromide
- CAS:
- 56-94-0
- MF:
- C32H52Br2N4O4
- Structure:
- Chemical Name:
- Anisodine hydrobromide
- CAS:
- 76822-34-9
- MF:
- C17H21NO5.BrH
- Structure:
- Chemical Name:
- Etybenzatropine
- CAS:
- 524-83-4
- MF:
- C22H27NO
- Structure:
- Chemical Name:
- HOMATROPINE
- CAS:
- 87-00-3
- MF:
- C16H21NO3
- Chemical Name:
- HYOSCINE N BUTYL BROMIDE BP
- Structure:
- Chemical Name:
- Dihydrogalanthamine
- CAS:
- 21133-52-8
- MF:
- C17H23NO3
- Structure:
- Chemical Name:
- Atropine sulfate
- CAS:
- 55-48-1
- MF:
- 2C17H23NO3.H2O4S
- Structure:
- Chemical Name:
- ANISODAMINE HYDROBROMIDE
- CAS:
- 55449-49-5
- MF:
- C7H10BrNO
- Structure:
- Chemical Name:
- Cuscohygrine
- CAS:
- 454-14-8
- MF:
- C13H24N2O
- Structure:
- Chemical Name:
- ANISODAMINE
- CAS:
- 55869-99-3
- MF:
- C17H23NO4
- Structure:
- Chemical Name:
- OLEYLOXYETHYL PHOSPHORYLCHOLINE
- CAS:
- 84601-19-4
- MF:
- C25H52NO5P
- Structure:
- Chemical Name:
- Scopolamine
- CAS:
- 51-34-3
- MF:
- C17H21NO4
- Chemical Name:
- Racanisodamine