HOMATROPINE METHYL BROMIDE Chemical Properties

Melting point:

192°C

storage temp. 

-20°C Freezer

solubility 

Freely soluble in water, soluble in ethanol 96 per cent

color 

White to Off-White

Merck 

14,4730

CAS DataBase Reference

80-49-9(CAS DataBase Reference)

EPA Substance Registry System

Homatropine methylbromide (80-49-9)

Safety Information

Risk Statements 

20/21/22

Safety Statements 

22-26-36

RIDADR 

1544

WGK Germany 

3

RTECS 

MS9000000

HazardClass 

6.1

PackingGroup 

III

HS Code 

29399990

Toxicity

LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)

HOMATROPINE METHYL BROMIDE Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless crystals

Uses

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Uses

anticholinergic (opthalmic)

brand name

Equipin (Mission); Homapin (Mission).

General Description

Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).

Clinical Use

Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.

HOMATROPINE METHYL BROMIDE(80-49-9)Related Product Information

• Butyl lactate
• FEMA 3457
• HOMATROPINE METHYL BROMIDE
• 4-PROPOXY-PIPERIDINE
• ETHYL MANDELATE
• 6-DIMETHYLAMINO-1-HEXANOL
• 8-METHYL-8-AZABICYCLO[3.2.1]OCTANE
• 4-Methoxypiperidine
• Flutropium bromide
• Cycloheptanol
• Homatropine Hydrobromide
• PETIOLE
• tropenziline bromide
• CYCLOHEPTYLAMINE
• ISOPROPYL PHENYLACETATE
• HOMATROPINE
• Nortropine hydrochloride
• 4-ETHOXY-PIPERIDINE >98%