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Pilocarpine nitrate

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Pilocarpine nitrate Basic information

Product Name:
Pilocarpine nitrate
Synonyms:
  • 3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)-METHYL]-2-(3H)-FURANONE NITRATE
  • 2(3H)-Furanone, 3-ethyldihydro-4-(1-methyl-1H-imidazol-5-yl)methyl-, (3S,4R)-, mononitrate
  • PILOCARPINENITRATE,CRYSTAL,USP
  • Pilagan
  • Pilocarpinnitrat
  • (3S)-3-Ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one nitrate
  • (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone mononitrate
  • Pilocarpini nitras
CAS:
148-72-1
MF:
C11H17N3O5
MW:
271.27
EINECS:
205-723-7
Product Categories:
  • Inhibitors
  • AgonistsDrugs of Abuse
  • Chemical Structure
  • Cholinergics
  • Neurotransmitters
  • Others
  • Alkaloids
  • Alkaloids (Others)
  • Biochemistry
  • API
Mol File:
148-72-1.mol
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Pilocarpine nitrate Chemical Properties

Melting point:
173,5-174°C
alpha 
D +77 to +83° (c = 10)
refractive index 
81 ° (C=2, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, very faintly yellow
form 
powder
color 
white
optical activity
[α]25/D +83°, c = 10 in H2O(lit.)
Merck 
14,7424
BRN 
4171406
CAS DataBase Reference
148-72-1(CAS DataBase Reference)
EPA Substance Registry System
Pilocarpine nitrate (148-72-1)
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Safety Information

Hazard Codes 
Xn,T+
Risk Statements 
22-26/28
Safety Statements 
1-25-45
RIDADR 
3087
WGK Germany 
3
RTECS 
TK1455000
3-10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939800000
Toxicity
LD50 oral in rat: 911mg/kg

MSDS

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Pilocarpine nitrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless crystals, sensitive to light.

Uses

antiglaucoma agent, miotic

Uses

Antiglaucoma drug;Cholinergic

Uses

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

brand name

Pilagan (Allergan).

General Description

Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Pilocarpine nitrateSupplier

Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
Email
market03@meryer.com
LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
Syntechem Co.,Ltd
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info@syntechem.com
Hangzhou Yuhao Chemical Technology Co., Ltd
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0571-82693216
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info@yuhaochemical.com
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com