Pilocarpine nitrate Chemical Properties

Melting point:

173,5-174°C

alpha 

D +77 to +83° (c = 10)

refractive index 

81 ° (C=2, H2O)

storage temp. 

2-8°C

solubility 

H₂O: 0.1 g/mL, clear, very faintly yellow

form 

powder

color 

white

optical activity

[α]25/D +83°, c = 10 in H2O(lit.)

Merck 

14,7424

BRN 

4171406

CAS DataBase Reference

148-72-1(CAS DataBase Reference)

EPA Substance Registry System

Pilocarpine nitrate (148-72-1)

Safety Information

Hazard Codes 

Xn,T+

Risk Statements 

22-26/28

Safety Statements 

1-25-45

RIDADR 

3087

WGK Germany 

3

RTECS 

TK1455000

F 

3-10

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2939800000

Toxicity

LD50 oral in rat: 911mg/kg

MSDS

• Language:English Provider:SigmaAldrich

Pilocarpine nitrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless crystals, sensitive to light.

Uses

antiglaucoma agent, miotic

Uses

Antiglaucoma drug;Cholinergic

Uses

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

brand name

Pilagan (Allergan).

General Description

Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Pilocarpine nitrate(148-72-1)Related Product Information

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