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Pilocarpine nitrate

Product Name
Pilocarpine nitrate
CAS No.
148-72-1
Chemical Name
Pilocarpine nitrate
Synonyms
Nitrat;Pilocarpine nitrate for system suitability CRS;Pilagan;pilofrin;Pilocarpinnitrat;Einecs 205-723-7;Pilocarpin Nitrate;Pilocarpini nitras;PILOCARPINE NITRATE;p.v.carpineliquifilm
CBNumber
CB4237796
Molecular Formula
C11H17N3O5
Formula Weight
271.27
MOL File
148-72-1.mol
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Pilocarpine nitrate Property

Melting point:
173,5-174°C
alpha 
D +77 to +83° (c = 10)
refractive index 
81 ° (C=2, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, very faintly yellow
form 
powder
color 
white
optical activity
[α]25/D +83°, c = 10 in H2O(lit.)
Merck 
14,7424
BRN 
4171406
CAS DataBase Reference
148-72-1(CAS DataBase Reference)
EPA Substance Registry System
Pilocarpine nitrate (148-72-1)
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Safety

Hazard Codes 
Xn,T+
Risk Statements 
22-26/28
Safety Statements 
1-25-45
RIDADR 
3087
WGK Germany 
3
RTECS 
TK1455000
3-10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939800000
Toxicity
LD50 oral in rat: 911mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H272May intensify fire; oxidizer

H302Harmful if swallowed

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P220Keep/Store away from clothing/…/combustible materials.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0597
Product name
Pilocarpine nitrate
Purity
meets USP testing specifications
Packaging
5g
Price
$439
Updated
2024/03/01
Sigma-Aldrich
Product number
P0597
Product name
Pilocarpine nitrate
Purity
meets USP testing specifications
Packaging
25g
Price
$918
Updated
2024/03/01
Sigma-Aldrich
Product number
BP503
Product name
Pilocarpine nitrate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
200MG
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000106
Product name
Pilocarpine nitrate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000106
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
P6628
Product name
Pilocarpine nitrate salt
Purity
≥98% (HPLC)
Packaging
10g
Price
$244
Updated
2024/03/01
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Pilocarpine nitrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder or colourless crystals, sensitive to light.

Uses

antiglaucoma agent, miotic

Uses

Antiglaucoma drug;Cholinergic

Uses

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

brand name

Pilagan (Allergan).

General Description

Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Pilocarpine nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pilocarpine nitrate Suppliers

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2876
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from Pilocarpine nitrate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Pilocarpine nitrate 148-72-1
Price
US $35.00-1.30/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Dideu Industries Group Limited
Product
Pilocarpine nitrate 148-72-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27

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