ChemicalBook > CAS DataBase List > SECURININE

SECURININE

Product Name
SECURININE
CAS No.
5610-40-2
Chemical Name
SECURININE
Synonyms
securinin;SECURININE;Securan one;(-)-securinin;(-)-Securinin;SECURAN-11-ONE;(-)-SECURININE;SECURININE(RG);(–)-Securinine;Securinan-11-on
CBNumber
CB8247560
Molecular Formula
C13H15NO2
Formula Weight
217.26
MOL File
5610-40-2.mol
More
Less

SECURININE Property

Melting point:
140-1420C
alpha 
D20 -1042° (c = 1 in alc)
Boiling point:
357.82°C (rough estimate)
Density 
1.30±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5300 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥25mg/mL
form 
powder
pka
8.29±0.20(Predicted)
color 
yellow
optical activity
[α]/D -980 to -1015 (C=1, MeOH)
More
Less

Safety

Hazard Codes 
T,Xn
Risk Statements 
23/24/25-22
Safety Statements 
36/37/39-45
WGK Germany 
3
RTECS 
VS4115000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0055
Product name
Securinine
Purity
≥98% (HPLC)
Packaging
25mg
Price
$298
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
10mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
25mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
50mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
100mg
Price
$356
Updated
2024/03/01
More
Less

SECURININE Chemical Properties,Usage,Production

Description

A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]20D - 1106°(CHC13), [α]30D - 1106°(CHC13) and[α]20D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.

Chemical Properties

Yellow Solid

Uses

GABAA receptor blocker, CNS stimulant

Uses

Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.

Definition

ChEBI: Securinine is a member of indolizines.

References

Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)

SECURININE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SECURININE Suppliers

Chengdu Herbpurify Co.Ltd.
Tel
18302802153 18981717076
Fax
086-28-85377358
Email
2355253619@qq.com
Country
China
ProdList
1104
Advantage
58
Huzhou ZhanShu Biotechnology Co.,Ltd
Tel
0572-8889530 18167260939
Email
zsubio@163.com
Country
China
ProdList
357
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
More
Less

View Lastest Price from SECURININE manufacturers

Dideu Industries Group Limited
Product
SECURININE 5610-40-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28
Career Henan Chemical Co
Product
SECURININE 5610-40-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

5610-40-2, SECURININERelated Search:


  • SECURAN-11-ONE
  • SECURININE
  • (-)-securinin
  • securinan-11-one
  • (-)-SECURININE
  • securinin
  • Securinan-11-on
  • SECURININE(RG)
  • (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
  • 1,2,3,4,10,10a-Hexahydro-10-hydroxy-
  • (2β,7S,9S)-Securinan-11-one
  • Securan one
  • Securinine, 98%, from Flueggea suffruticosa (Pall.) Baill.
  • 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-
  • (–)-Securinine
  • SECURININE USP/EP/BP
  • (-)-Securinin
  • 5610-40-2
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals