SECURININE
- Product Name
- SECURININE
- CAS No.
- 5610-40-2
- Chemical Name
- SECURININE
- Synonyms
- securinin;SECURININE;Securan one;(-)-securinin;SECURAN-11-ONE;(-)-SECURININE;SECURININE(RG);(–)-Securinine;Securinan-11-on;securinan-11-one
- CBNumber
- CB8247560
- Molecular Formula
- C13H15NO2
- Formula Weight
- 217.26
- MOL File
- 5610-40-2.mol
SECURININE Property
- Melting point:
- 140-1420C
- alpha
- D20 -1042° (c = 1 in alc)
- Boiling point:
- 357.82°C (rough estimate)
- Density
- 1.30±0.1 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥25mg/mL
- form
- powder
- pka
- 8.29±0.20(Predicted)
- color
- yellow
- optical activity
- [α]/D -980 to -1015 (C=1, MeOH)
- InChI
- InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
- InChIKey
- SWZMSZQQJRKFBP-WZRBSPASSA-N
- SMILES
- N12CCCC[C@]1([H])[C@]13C[C@@]2([H])C=CC1=CC(=O)O3
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 23/24/25-22
- Safety Statements
- 36/37/39-45
- WGK Germany
- 3
- RTECS
- VS4115000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0055
- Product name
- Securinine
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $261
- Updated
- 2025/07/31
- Product number
- 24902
- Product name
- (–)-Securinine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 24902
- Product name
- (–)-Securinine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 24902
- Product name
- (–)-Securinine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 24902
- Product name
- (–)-Securinine
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $356
- Updated
- 2024/03/01
SECURININE Chemical Properties,Usage,Production
Description
A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]20D - 1106°(CHC13), [α]30D - 1106°(CHC13) and[α]20D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.
Chemical Properties
Yellow Solid
Uses
GABAA receptor blocker, CNS stimulant
Uses
Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.
Definition
ChEBI: Securinine is a member of indolizines.
in vivo
In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period[2].
References
Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)
SECURININE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SECURININE manufacturers
- Product
- SECURININE 5610-40-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-15
- Product
- SECURININE 5610-40-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-28
- Product
- SECURININE 5610-40-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-12