ChemicalBook > CAS DataBase List > SECURININE

SECURININE

Product Name
SECURININE
CAS No.
5610-40-2
Chemical Name
SECURININE
Synonyms
securinin;SECURININE;Securan one;(-)-securinin;SECURAN-11-ONE;(-)-SECURININE;SECURININE(RG);(–)-Securinine;Securinan-11-on;securinan-11-one
CBNumber
CB8247560
Molecular Formula
C13H15NO2
Formula Weight
217.26
MOL File
5610-40-2.mol
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SECURININE Property

Melting point:
140-1420C
alpha 
D20 -1042° (c = 1 in alc)
Boiling point:
357.82°C (rough estimate)
Density 
1.30±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5300 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥25mg/mL
form 
powder
pka
8.29±0.20(Predicted)
color 
yellow
optical activity
[α]/D -980 to -1015 (C=1, MeOH)
InChI
InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
InChIKey
SWZMSZQQJRKFBP-WZRBSPASSA-N
SMILES
N12CCCC[C@]1([H])[C@]13C[C@@]2([H])C=CC1=CC(=O)O3
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Safety

Hazard Codes 
T,Xn
Risk Statements 
23/24/25-22
Safety Statements 
36/37/39-45
WGK Germany 
3
RTECS 
VS4115000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0055
Product name
Securinine
Purity
≥98% (HPLC)
Packaging
25mg
Price
$261
Updated
2025/07/31
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
10mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
25mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
50mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
24902
Product name
(–)-Securinine
Purity
≥98%
Packaging
100mg
Price
$356
Updated
2024/03/01
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SECURININE Chemical Properties,Usage,Production

Description

A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]20D - 1106°(CHC13), [α]30D - 1106°(CHC13) and[α]20D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.

Chemical Properties

Yellow Solid

Uses

GABAA receptor blocker, CNS stimulant

Uses

Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.

Definition

ChEBI: Securinine is a member of indolizines.

in vivo

In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period[2].

References

Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)

SECURININE Preparation Products And Raw materials

Raw materials

Preparation Products

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SECURININE Suppliers

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View Lastest Price from SECURININE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
SECURININE 5610-40-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-15
Dideu Industries Group Limited
Product
SECURININE 5610-40-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28
Career Henan Chemical Co
Product
SECURININE 5610-40-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

5610-40-2, SECURININERelated Search:

Arecoline hydrobromide Isosorbide dinitrate Colchicine Daurinoline daurisoline L-Hyoscyamine VERATRIDINE Xanthiazone hygrine Concentrated sulfuric acid Allasecurinine SECURININE conhydrine 3-METHYLPYRROLIDIN-3-OL ACETIC ACID 2-METHYL-4-PENTEN-2-YL ESTER SECURININE HNO3 SECURININE NITRATE AKOS NCG1-0031

  • SECURAN-11-ONE
  • SECURININE
  • (-)-securinin
  • securinan-11-one
  • (-)-SECURININE
  • securinin
  • Securinan-11-on
  • SECURININE(RG)
  • (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one
  • 1,2,3,4,10,10a-Hexahydro-10-hydroxy-
  • (2β,7S,9S)-Securinan-11-one
  • Securan one
  • Securinine, 98%, from Flueggea suffruticosa (Pall.) Baill.
  • 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-
  • (–)-Securinine
  • SECURININE USP/EP/BP
  • 5610-40-2
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals