SECURININE

Product Name: SECURININE
CAS No.: 5610-40-2
Chemical Name: SECURININE
Synonyms: securinin;SECURININE;Securan one;(-)-securinin;(-)-Securinin;SECURAN-11-ONE;(-)-SECURININE;SECURININE(RG);(–)-Securinine;Securinan-11-on
CBNumber: CB8247560
Molecular Formula: C13H15NO2
Formula Weight: 217.26
MOL File: 5610-40-2.mol

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SECURININE Property

Melting point:: 140-1420C
alpha: D20 -1042° (c = 1 in alc)
Boiling point:: 357.82°C (rough estimate)
Density: 1.30±0.1 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5300 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ≥25mg/mL
form: powder
pka: 8.29±0.20(Predicted)
color: yellow
optical activity: [α]/D -980 to -1015 (C=1, MeOH)

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Safety

Hazard Codes: T,Xn
Risk Statements: 23/24/25-22
Safety Statements: 36/37/39-45
WGK Germany: 3
RTECS: VS4115000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0055
Product name: Securinine
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $298
Updated: 2024/03/01

Cayman Chemical

Product number: 24902
Product name: (–)-Securinine
Purity: ≥98%
Packaging: 10mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 24902
Product name: (–)-Securinine
Purity: ≥98%
Packaging: 25mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 24902
Product name: (–)-Securinine
Purity: ≥98%
Packaging: 50mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 24902
Product name: (–)-Securinine
Purity: ≥98%
Packaging: 100mg
Price: $356
Updated: 2024/03/01

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SECURININE Chemical Properties,Usage,Production

Description

A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]²⁰_D - 1106°(CHC1₃), [α]³⁰_D - 1106°(CHC1₃) and[α]²⁰_D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.

Chemical Properties

Yellow Solid

Uses

GABAA receptor blocker, CNS stimulant

Uses

Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.

Definition

ChEBI: Securinine is a member of indolizines.

References

Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)

SECURININE Preparation Products And Raw materials

Raw materials

Preparation Products

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SECURININE Suppliers

Canada 1 China 130 Europe 2 Germany 1 India 1 Switzerland 1 United Kingdom 8 United States 23 Global 167

Chengdu Herbpurify Co.Ltd.

Tel: 18302802153 18981717076
Fax: 086-28-85377358
Email: 2355253619@qq.com
Country: China
ProdList: 1104
Advantage: 58

Huzhou ZhanShu Biotechnology Co.,Ltd

Tel: 0572-8889530 18167260939
Email: zsubio@163.com
Country: China
ProdList: 358
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

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View Lastest Price from SECURININE manufacturers

Dideu Industries Group Limited

Product: SECURININE 5610-40-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

Career Henan Chemical Co

Product: SECURININE 5610-40-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

5610-40-2, SECURININERelated Search:

Arecoline hydrobromide Isosorbide dinitrate Colchicine Daurinoline daurisoline L-Hyoscyamine VERATRIDINE Xanthiazone hygrine Concentrated sulfuric acid Allasecurinine SECURININE conhydrine 3-METHYLPYRROLIDIN-3-OL ACETIC ACID 2-METHYL-4-PENTEN-2-YL ESTER SECURININE HNO3 SECURININE NITRATE AKOS NCG1-0031

SECURAN-11-ONE

SECURININE

(-)-securinin

securinan-11-one

(-)-SECURININE

securinin

Securinan-11-on

SECURININE(RG)

(6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one

1,2,3,4,10,10a-Hexahydro-10-hydroxy-

(2β,7S,9S)-Securinan-11-one

Securan one

Securinine, 98%, from Flueggea suffruticosa (Pall.) Baill.

8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-

(–)-Securinine

SECURININE USP/EP/BP

(-)-Securinin

5610-40-2

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals