Thiamine nitrate Chemical Properties

Melting point:

374-392 °C

storage temp. 

2-8°C

solubility 

Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol.

form 

solid

pka

4.8(at 25℃)

color 

White to Off-White

Odor

wh. cryst. or cryst. powd., sl. char. odor

Merck 

14,9295

BRN 

3857790

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

UIERGBJEBXXIGO-UHFFFAOYSA-N

CAS DataBase Reference

532-43-4(CAS DataBase Reference)

EPA Substance Registry System

Thiamine nitrate (532-43-4)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

1

RTECS 

XI7400000

TSCA 

Yes

HS Code 

29362200

Thiamine nitrate Usage And Synthesis

Description

Thiamine nitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. It occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations.
Thiamine nitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour.

References

[1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995
[2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008
[3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369

Description

Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3^-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).

Chemical Properties

White or almost white, crystalline powder or small, colourless crystals.

Uses

Thiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function.

Uses

Vitamin B1.

General Description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour.

Safety Profile

Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES.

Thiamine nitrate (532-43-4)Related Product Information

• Folic acid
• Methyl acrylate
• Thiamine hydrochloride
• Econazole nitrate
• Vitamin D3
• Ascorbic Acid
• Benzothiazole
• Thiamine chloride
• 2-Methyl-4-isothiazolin-3-one
• Fosthiazate
• Bensulfuron methyl
• Miconazole Nitrate
• 2,2'-Dithiobis(benzothiazole)
• Thiophanate-methyl
• Methylparaben
• NITRATE
• Benfotiamine
• Cocarboxylase