ALLOFERON 1 Chemical Properties

Boiling point:

2089.9±65.0 °C(Predicted)

Density 

1.422±0.06 g/cm3(Predicted)

form 

Solid

pka

3.18±0.10(Predicted)

color 

White to off-white

Sequence

His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly

ALLOFERON 1 Usage And Synthesis

Uses

Alloferon 1 is an antiviral and antitumoral peptide. Alloferon 1 stimulates natural cytotoxicity of human peripheral blood lymphocytes. Alloferon 1 also induces IFN synthesis, and enhances antiviral and antitumor resistance in mice. Alloferon 1 also shows anti-inflammatory activity in λ-carrageenan-induced paw edema model. Alloferon 1 can be isolated from the blood of the blow fly Calliphora vicina (Diptera)[1][2][3].

References

[1] Chernysh S, et al. Antiviral and antitumor peptides from insects. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32. DOI:10.1073/pnas.192301899
[2] Zhang X, et al. Alloferon-1 ameliorates acute inflammatory responses in λ-carrageenan-induced paw edema in mice. Sci Rep. 2022 Oct 6;12(1):16689. DOI:10.1038/s41598-022-20648-z

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