TM2-115
TM2-115 Basic information
- Product Name:
- TM2-115
- Synonyms:
-
- TM2-115
- 4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-7-(phenylmethoxy)-
- TM2-115 [7-Benzyloxy-6-methoxy-2-(1-methyl-azepan-4-yl)- quinazolin-4-yl]-(1-methyl-piperidin-4-yl)-amine
- [7-Benzyloxy-6-methoxy-2-(1-methyl-azepan-4-yl)- quinazolin-4-yl]-(1-methyl-piperidin-4-yl)-amine
- 7-(Benzyloxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
- TM2-115, 10 mM in DMSO
- CAS:
- 1197196-47-6
- MF:
- C28H38N6O2
- MW:
- 490.64
- Mol File:
- 1197196-47-6.mol
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TM2-115 Chemical Properties
- Boiling point:
- 662.3±65.0 °C(Predicted)
- Density
- 1.188±0.06 g/cm3(Predicted)
- solubility
- DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml - form
- Solid
- pka
- 9.34±0.70(Predicted)
- color
- White to off-white
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TM2-115 Usage And Synthesis
Uses
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death[1].
References
[1] Malmquist NA, et al. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. DOI:10.1073/pnas.1205414109
[2] SANDEEP SUNDRIYAL. Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.[J]. MedChemComm, 2017: 1069-1092. DOI: 10.1039/c7md00052a
TM2-115Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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ShangHai Biochempartner Co.,Ltd
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Shanghai Chaolan Chemical Technology Center
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MQ (shanghai) Pharmaceuticals Co., Ltd.
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- 13761635123
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