3-Furoic acid Chemical Properties

Melting point:

120-122 °C (lit.)

Boiling point:

229.64°C

Density 

1.3220

refractive index 

1.4710 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

3.9(at 25℃)

color 

Off-White to Beige

Water Solubility 

insoluble

BRN 

108638

InChIKey

IHCCAYCGZOLTEU-UHFFFAOYSA-N

LogP

1.030

CAS DataBase Reference

488-93-7(CAS DataBase Reference)

NIST Chemistry Reference

3-Furancarboxylic acid(488-93-7)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34

Safety Statements 

26-36/37-45-36/37/39-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29321900

MSDS

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3-Furoic acid Usage And Synthesis

Description

3-Furoic acid, also known as 3-carboxyfuran or 3-furoate, belongs to the class of organic compounds known as furoic acids. These are organic compounds containing a furoic acid moiety, with a structure characterized by a furan ring bearing a carboxylic acid group at the C2 or C3 carbon atom.
3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. It is used in synthesis of furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. It exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.

Chemical Properties

white to light yellow crystal powde

Uses

3-Furoic acid can be used as a reactant to synthesize:
Furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction.
(±)-Hyperolactone A by reacting with 2-methylbutanal.
Furo[2,3-b]pyridin-4-one-5-carboxylate ester derivatives as potential non-nucleoside inhibitors of human herpesvirus polymerases.

Uses

3-Furoic acid is used in synthesis of furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. It exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.

Uses

3-Furoic acid can be used as a reactant to synthesize:

• Furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction.
• (±)-Hyperolactone A by reacting with 2-methylbutanal.
• Furo[2,3-b]pyridin-4-one-5-carboxylate ester derivatives as potential non-nucleoside inhibitors of human herpesvirus polymerases.

Definition

ChEBI: A furoic acid carrying the carboxy group at position 3.

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 1509, 1985 DOI: 10.1016/S0040-4039(00)98538-1

Biological Activity

3-Furoic acid exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.

Biochem/physiol Actions

3-Furoic acid exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.

Purification Methods

Crystallise the acid from water or aqueous EtOH, and sublime it in a vacuum. [Beilstein 18 I 439, 18 III/IV 4052, 18/6 V 196.]

3-Furoic acid(488-93-7)Related Product Information

• 2-FURAMIDE
• Folic acid
• Benzoic acid
• Furfurylamine
• Calcium formate
• 2,5-Furandicarboxylic acid
• FURFURYL ALCOHOL RESIN
• Furazolidone
• Citric acid
• Retinoic acid
• 2-Furoyl chloride
• Hyaluronic acid
• Tetrahydrofuran
• Ethyl 2-(Chlorosulfonyl)acetate
• Ascoric Acid
• 2-Tetrahydrofuroic acid
• Ethyl 3-furancarboxylate
• METHYL 2-METHYL-3-FUROATE