ATR inhibitor 1 Chemical Properties

Density 

1.68±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

6.48±0.46(Predicted)

form 

Solid

color 

Light yellow to yellow

ATR inhibitor 1 Usage And Synthesis

Uses

Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ[1].

References

[1] Nadia AHMAD, et al. Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof. WO2015187451A1
[2] Lin Li, et al. Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells DOI:10.1007/s13402-023-00817-6