PXS-5153A
PXS-5153A Basic information
- Product Name:
- PXS-5153A
- Synonyms:
-
- PXS-5153A
- (Z)-3-(1-(4-Amino-2-fluorobut-2-en-1-yl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N,N-dimethylbenzenesulfonamide Dihydrochloride
- MAO,PXS-5153A,PXS 5153A,PXS5153A,inhibit,Inhibitor,Monoamine Oxidase
- LOX-IN-3 (PXS-5505)
- 3-{1-[(2Z)-4-Amino-2-fluorobut-2-en-1-yl]-2-methylpyrrolo[3,2-b]pyridin-3-yl}-N,N-dimethylbenzenesulfonamide dihydrochloride - [AC80868]
- CAS:
- 2125956-82-1
- MF:
- C20H24ClFN4O2S
- MW:
- 438.95
- Mol File:
- 2125956-82-1.mol
PXS-5153A Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
PXS-5153A Usage And Synthesis
Uses
A useful intermediate in the preparation of haloallylamine indole and azaindole derivatives which are lysyl oxidases inhibitors.
in vivo
As expected, rhLOXL2 dose-dependently induce oxidation of collagen with PXS-5153A dose-dependently impeding collagen oxidation. Therapeutic treatment of PXS-5153A substantially reduces immature crosslink formation compared with the CCl4 treated animals. Mature crosslink formation is also reduced by PXS-5153A treatment. All groups with therapeutic treatment of PXS-5153A show a significant reduction in DHLNL formation compared to the CCl4 treated animals. Treatment with PXS-5153A causes a significantly reduction in HYP compared to the CCl4 group. In addition, the amount of fibrillar collagen is markedly augmented by disease as seen by the 2.2-fold increase in percentage coverage area by Picrosirius red staining, which is reduced by PXS-5153A[1].
PXS-5153ASupplier
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