Trimethylamine N-oxide dihydrate
Trimethylamine N-oxide dihydrate Basic information
- Product Name:
- Trimethylamine N-oxide dihydrate
- Synonyms:
-
- methanamineoxide,n,n-dimethyl,dihydrate
- n,n-dimethylmethanamineoxide,dihydrate
- trimethylammoniumoxidhydrat
- TMO
- TRIMETHYLAMINE N-OXIDE DIHYDRATE
- TRIMETHYLAMINE OXIDE DIHYDRATE
- TMANO
- TrimethylamineN-oxidedihydrate,98%
- CAS:
- 62637-93-8
- MF:
- C3H13NO3
- MW:
- 111.14
- EINECS:
- 678-501-4
- Product Categories:
-
- Amines
- Catalyst
- Oxidation
- Synthetic Organic Chemistry
- bc0001
- Mol File:
- 62637-93-8.mol
Trimethylamine N-oxide dihydrate Chemical Properties
- Melting point:
- 95-99 °C(lit.)
- Flash point:
- 95 °C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Fine Crystalline Powder
- color
- White to off-white
- Water Solubility
- Soluble in water, ethanol, dimethyl sulfoxide and methanol. Sparingly soluble in hot chloroform. Insoluble in diethyl ether, benzene and hydrocarbon solvents.
- Merck
- 14,9711
- BRN
- 3612927
- Cosmetics Ingredients Functions
- FRAGRANCE
HUMECTANT - InChI
- InChI=1S/C3H9NO.2H2O/c1-4(2,3)5;;/h1-3H3;2*1H2
- InChIKey
- PGFPZGKEDZGJQZ-UHFFFAOYSA-N
- SMILES
- [N+]([O-])(C)(C)C.O.O
- CAS DataBase Reference
- 62637-93-8(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 2
- RTECS
- YH2850000
- F
- 4.10
- TSCA
- Yes
- HS Code
- 29211990
MSDS
- Language:English Provider:Trimethylamine N-oxide dihydrate
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Trimethylamine N-oxide dihydrate Usage And Synthesis
Chemical Properties
white crystalline powder
Uses
Trimethylamine N-Oxide Dihydrate is as an oxygen transfer agent used to promote heterometallic cluster catalyzing coordinative hydrogenation. Trimethylamine N-Oxide Dihydrate is also used as a catalyst in the preparation of thermally stable TiO2 nanorod incorporated polymers and semiconductor/metal nanocomposites.
Uses
Trimethylamine N-oxide dihydrate is used as an oxidizing agent in organic synthesis. It is also used to make quaternary ammonium compounds and a warning agent for flammable gas. Further, it acts as a flavoring agent or adjuvant. It serves as an oxidant for the catalytic osmium tetraoxide cis-hydroxylation of hindered olefins. In addition to this, it is used as a reactant for C-H bond cleavage and decarbonylating agent for solvent-free reactions.
Uses
Oxidizing reagent in organic synthesis.
General Description
Trimethylamine N-oxide (TMAO) is an amphiphilic osmolyte that can counteract the denaturing effects of urea, pressure, and ice and stabilize the proteins.
reaction suitability
reagent type: oxidant
in vivo
Trimethylamine N-oxide (TMAO) dihydrate contributes to cardiovascular diseases by promoting inflammatory responses. C57BL/6 mice are fed a normal diet, high-choline diet and/or 3-dimethyl-1-butanol (DMB) diet. The levels of Trimethylamine N-oxide dihydrate and choline are increased in choline-fed mice. Left ventricular hypertrophy, pulmonary congestion, and diastolic dysfunction are markedly exacerbated in heart failure with preserved ejection fraction (HFpEF) mice fed high-choline diets compared with mice fed the control diet. Myocardial fibrosis and inflammation were markedly increased in HFpEF mice fed high-choline diets compared with animals fed the control diet[1].
Trimethylamine N-oxide (dihydrate) can be used in animal modeling to construct models of cardiovascular and metabolic diseases[1].
Administration: 100 μM and 1 mM? perfusion or incubation in TMAO-containing buffer solution? incubated for 1 h[1]
Mice: CD-1? male? weighing 25-30 g? 6-8 weeks of age[1]
Administration: 120 mg/kg? mixed with drinking water? a single dose or daily for 7 days[1]
(2)All experimental animals were housed under standard conditions (21-23℃, 12-hour light/dark cycle, relative humidity 45-65%) with unlimited access to food (R70 diet) and water[1].
(3)The mice from the first experimental group received Isoproterenol (HY-B1670A) at a dose of 10 μg/mouse, but the animals from the second group received Isoproterenol (HY-B1670A) and Trimethylamine N-oxide (dihydrate) at doses of 10 μg/mouse and 120 mg/kg, respectively. After 30 min, the experimental animals were anesthetized with isoflurane once more to record the cardiac response to acute cardiac stress and the impact of Trimethylamine N-oxide (dihydrate) on the inotropic and chronotropic effects. For the next seven days, the mice in the second group received Trimethylamine N-oxide (dihydrate) together with drinking water at a dose of 120 mg/kg, while the animals from the first group received pure drinking water[1].
Pathology change: Trimethylamine N-oxide (dihydrate) had no influence on Isoproterenol (HY-B1670A)-induced increase on left ventricular ejection fraction, fractional shortening and heart rate[1].
Histological analysis: Promote myocardial hypertrophy, fibrosis, and inflammation in a model of cardiovascular disease (CVD)[3].
IC 50
Human Endogenous Metabolite; NLRP3; Microbial Metabolite
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