Flavomarein，2R-3',4',8-Trihydroxyflavanone-7-O-glucoside Chemical Properties

Melting point:

236-239 °C

Boiling point:

818.2±65.0 °C(Predicted)

Density 

1.665±0.06 g/cm3(Predicted)

pka

7.58±0.40(Predicted)

Flavomarein，2R-3',4',8-Trihydroxyflavanone-7-O-glucoside Usage And Synthesis

Uses

(2R)-Flavanomarein is a predominant flavonoid of Coreopsis tinctoria Nutt with protective effects against diabetic nephropathy. (2R)-Flavanomarein has good antioxidative, antidiabetic, antihypertensive and anti-hyperlipidemic activities[1][2].

References

[1] Nan-Nan Zhang, et al. Flavanomarein inhibits high glucose-stimulated epithelial-mesenchymal transition in HK-2 cells via targeting spleen tyrosine kinase. Sci Rep. 2020 Jan 16;10(1):439. DOI:10.1038/s41598-019-57360-4
[2] Liang Le, et al. The protective effects of the native flavanone flavanomarein on neuronal cells damaged by 6-OHDA. Phytomedicine. 2019 Feb;53:193-204. DOI:10.1016/j.phymed.2018.09.005