QUINELORANE 2HCL
QUINELORANE 2HCL Basic information
- Product Name:
- QUINELORANE 2HCL
- Synonyms:
-
- QUINELORANE 2HCL
- Quinelorane hydrochloride
- (5aR,9aR)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-aminedihydrochloride
- QUINELORANE DIHYDROCHLORIDE (LY-163,502) D2 DOPAMINE RECEPTOR
- LY-163,502, (5aR-trans)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-amine dihydrochloride
- CAS:
- 97548-97-5
- MF:
- C14H23ClN4
- MW:
- 282.82
- Mol File:
- 97548-97-5.mol
QUINELORANE 2HCL Chemical Properties
- storage temp.
- Desiccate at RT
- solubility
- H2O: >10mg/mL
- form
- Powder
- color
- white
- Water Solubility
- Soluble to 25 mM in water
QUINELORANE 2HCL Usage And Synthesis
Uses
Antihypertensive; antiparkinsonian.
Uses
Quinelorane Dihydrochloride is a D2DR agonist.
Biological Activity
Dopamine D 2 and D 3 receptor agonist; K i values are 5.7 and 3.4 nM respectively.
in vivo
Quinelorane dihydrochloride (LY163502; 0.003, 0.01 mg/kg; s.c.) reduces GABA efflux, with significant effects with 0.01 but not 0.003 mg/kg in male Wistar rats (300 g)[1].
Quinelorane dihydrochloride (0.032, 0.32, 3.2, 5.6 mg/kg; IP) significantly and dose-dependently increases locomotor activity in the Sprague Dawley rats. There was no main effect of sex and sex interaction[1].
Quinelorane dihydrochloride significantly decreases activity in the male and female inbred FVB/NJ, BALB/cJ, BALB/cByJ, C57BL/6J, Swiss Webster, A/J, DBA/2J, 129S1/SvImJ, and 129S6/SvEvTac mice[1].
IC 50
D2 Receptor; D3 Receptor
storage
Desiccate at RT
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