Anecortave Acetate Chemical Properties

Melting point:

230-234°C

alpha 

D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3).

Boiling point:

551.8±50.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

12.47±0.60(Predicted)

form 

Solid

color 

Off-White to Beige

Anecortave Acetate Usage And Synthesis

Description

Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.

Chemical Properties

Off-White Solid

Uses

As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.

Definition

ChEBI: Anecortave acetate is an organic molecular entity.

Synthesis

Anecortave has been synthesized by several different routes, and Pharmacia process patents are cited here. The synthesis is depicted in the scheme. Compound 1 was condensed with 2-chlorovinyl ethyl ether with n-BuLi in THF at low temperature to give a mixture of two isomeric aldehydes 2 in 91% yield. The mixture 2 was treated with acetic anhydride and anhydrous potassium acetate in DMF at 106??C to give acetate 3 which was reacted with RhCl(PPh3)3 and triethylsilane in methylene chloride at 45??C for 4 hours to yield the corresponding triethylsilane ether 4 as a solid after crystallization in hexane. Finally, compound 4 was oxidized with 40% peracetic acid in toluene at low temperature, and the reaction was quenched with SO2 in methanol (2M), and treated with TEA to give anecortave acetate

Enzyme inhibitor

This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model.

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