METHYL 2-AMINO-6-FLUOROBENZOATE Chemical Properties

Boiling point:

266.6±25.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

1.18±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HS Code 

2916310090

METHYL 2-AMINO-6-FLUOROBENZOATE Usage And Synthesis

Synthesis

Example 134 (±)-5-[Acetyl-(3,5-bis(trifluoromethyl)benzyl)amino]-6-fluoro-tetrahydrobenzo[b]azepine-1-carboxylic acid Synthesis Procedure 1. Methyl 2-amino-6-fluorobenzoate Preparation: 2-amino-6-fluorobenzoic acid (3.00 g, 19.3 mmol) was dissolved in a ethyl acetate (59 mL) and ethanol (59 mL) (59 mL) and ethanol (59 mL) in a mixed solvent. Trimethylsilylated diazomethane (19.3 mL, 38.68 mmol, 2M in hexane) was slowly added to this solution and the reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford methyl 2-amino-6-fluorobenzoate (3.26 g, quantitative yield). Mass spectrum (electrospray positive ion mode): m/z 170 [M+H]+.

References

[1] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 131

METHYL 2-AMINO-6-FLUOROBENZOATE(86505-94-4)Related Product Information

• 5-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE
• 2-AMINO-6-FLUORO-3-NITROBENZOIC ACID ETHYL ESTER
• 2-AMINO-6-FLUOROBENZOIC ACID ETHYL ESTER
• 2-FLUORO-6-NITROBENZOIC ACID ETHYL ESTER
• 2-Amino-6-fluoro-benzoic acid methyl ester HCl
• 5,7-DIFLUORO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
• METHYL 2-AMINO-6-FLUOROBENZOATE
• 2-(2,6-DICHLORO-4-PYRIDYL)-5-FLUORO-4H-3,1-BENZOXAZIN-4-ONE
• 2-FLUORO-6-NITROBENZOIC ACID METHYL ESTER
• METHYL-2-ISOCYANO-6-FLUORBENZOATE
• METHYL 2-AMINO-6-FLUORO-3-NITROBENZOATE