GW284543
GW284543 Basic information
- Product Name:
- GW284543
- Synonyms:
-
- GW284543
- GW284543 (UNC10225170)
- UNC10225170
- 4-Quinolinamine, 6,7-dimethoxy-N-(3-phenoxyphenyl)-
- 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine
- Inhibitor,inhibit,GW 284543,GW284543,UNC 10225170,MIA PaCa-2,GW-284543,Mitogen-activated protein kinase kinase,MEK,MAPKK,UNC-10225170,MAP2K
- GW284543 HCl
- GW284543, 10 mM in DMSO
- CAS:
- 790186-68-4
- MF:
- C23H20N2O3
- MW:
- 372.42
- Mol File:
- 790186-68-4.mol
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GW284543 Chemical Properties
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO:67.0(Max Conc. mg/mL);179.9(Max Conc. mM)
- form
- Solid
- color
- Off-white to gray
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GW284543 Usage And Synthesis
Uses
GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
IC 50
MEK5
References
[1] Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. DOI:10.1016/j.ccell.2018.10.001
GW284543Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
- Tel
- 15076683720
- klq@cw-bio.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 17754423994 17754423994
- 2853530910@QQ.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 021-2022843681 15618226720
- lucy@atkchemical.com