CBX4 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

The polycomb group proteins contribute to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest. PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27. This histone methyl-transferase activity requires the Ezh2, Eed, and Suz12 subunits of the complex. Histone H3 methylation at Lys27 facilitates the recruitment of the second complex, PRC1, which ubiquitinylates histone H2A on Lys119. CBX4 is a component of the PRC1 complex, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit. CBX4 itself is a SUMO E3 ligase, and its function influences EMT, DNA damage response, tumor angiogenesis, and self-renewal.

References

[1] Boyer, L.A. et al. (2006) Nature 441, 349-53.
[2] Lee, T.I. et al. (2006) Cell 125, 301-13.
[3] Cao, R. et al. (2002) Science 298, 1039-43.
[4] Müller, J. et al. (2002) Cell 111, 197-208.
[5] Cao, R. and Zhang, Y. (2004) Mol Cell 15, 57-67.
[6] Wang, H. et al. (2004) Nature 431, 873-8.
[7] Satijn, D.P. et al. (1997) Mol Cell Biol 17, 6076-86.
[8] Cao, R. et al. (2005) Mol Cell 20, 845-54.
[9] Kagey, M.H. et al. (2003) Cell 113, 127-37.
[10] Li, B. et al. (2007) Biochem J 405, 369-378.

CBX4 antibody()Related Product Information

• KCND2 Antibody
• B3GALT4 Antibody
• Rabbit Polyclonal ABCC10 Antibody
• ONECUT3 antibody
• PSIP1 antibody
• RBP4 antibody
• Bcl3 antibody
• MAPK3 antibody
• CD1A antibody
• DAPK3 antibody