3-(4-BROMOPHENYL)PYRIDINE Chemical Properties

Melting point:

38.0 to 42.0 °C

Boiling point:

331.9±17.0 °C(Predicted)

Density 

1.426±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

4.70±0.10(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

InChI

InChI=1S/C11H8BrN/c12-11-5-3-9(4-6-11)10-2-1-7-13-8-10/h1-8H

InChIKey

FCHUOBPHXDXZBK-UHFFFAOYSA-N

SMILES

C1=NC=CC=C1C1=CC=C(Br)C=C1

Safety Information

HS Code 

2933.39.9200

3-(4-BROMOPHENYL)PYRIDINE Usage And Synthesis

Uses

3-(4-bromophenyl)pyridine is used in laboratory research and development and in chemical and pharmaceutical synthesis processes.

Chemical Properties

Pale yellow liquid

Synthesis

In a three-necked flask, p-bromoiodobenzene (28 g, 0.1 mol), pyridine-3-boronic acid (12.3 g, 0.1 mol), potassium carbonate (27.2 g, 200 mmol), tetrakis(triphenylphosphine)palladium (0.8 g), tetrahydrofuran (200 ml) and water (50 ml) were added. The reaction mixture was heated to reflux for 5 hours under nitrogen protection. After completion of the reaction, it was cooled to room temperature and filtered to remove insoluble material. The filtrate was purified by column chromatography to give 13 g of 3-(4-bromophenyl)pyridine in 56% yield.

References

[1] Patent: CN105753849, 2016, A. Location in patent: Paragraph 0056; 0057
[2] Chemistry - A European Journal, 2017, vol. 23, # 60, p. 15089 - 15097
[3] Patent: EP2065378, 2009, A1. Location in patent: Page/Page column 141

3-(4-BROMOPHENYL)PYRIDINE(129013-83-8)Related Product Information

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