2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Basic information
- Product Name:
- 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
- Synonyms:
-
- 2’-deoxyguanosine-5’-o-(1-thiotriphosphate),rpisomer(rp-dgtp-alpha-s),sodiumsalt
- RP-DGTP-ALPHA-S SODIUM SALT
- SP-DGTP-ALPHA-S SODIUM SALT
- 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
- 2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT
- Guanosine, 2'-deoxy-, 5'→P''-ester with [P''(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)) (9CI)
- dGTPαS (Rp isomer) 100mM Sodium Solution
- Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH))
- CAS:
- 80902-29-0
- MF:
- C10H12N5Na4O12P3S
- MW:
- 611.17
- Mol File:
- 80902-29-0.mol
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2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Chemical Properties
- Density
- 2.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
- solubility
- Water: Soluble
- pka
- 1.07±0.10(predicted)
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2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT Usage And Synthesis
Uses
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates[1].
References
[1] Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60(21):1682-1698. DOI:10.1021/acs.biochem.0c00944
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALTSupplier
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