4-Phenylbutanol Chemical Properties

Boiling point:

140-142 °C14 mm Hg(lit.)

Density 

0.984 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.521(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Almost insoluble in water, soluble in alcohol and oils

form 

Liquid

pka

15.13±0.10(Predicted)

color 

Clear colorless

Odor

Sweet, but rather heavy, herbaceous-rosy odor

Odor Type

floral

BRN 

2042122

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

InChIKey

LDZLXQFDGRCELX-UHFFFAOYSA-N

LogP

2.350

CAS DataBase Reference

3360-41-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzenebutanol(3360-41-6)

EPA Substance Registry System

Benzenebutanol (3360-41-6)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

34

Safety Statements 

23-24/25-45-36/37/39-27-26

WGK Germany 

3

RTECS 

222-128-8

TSCA 

Yes

HS Code 

29062900

MSDS

• Language:English Provider:4-Phenylbutanol
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4-Phenylbutanol Usage And Synthesis

Chemical Properties

colourless liquid

Uses

4-Phenyl-1-butanol is used as a reagent in the synthesis of substituted pyrrolidine-2-carboxylic acids which are used in the treatment of AT2 receptor function associated diseases.

Uses

4-Phenyl-1-butanol was used in synthesis of NK105, a paclitaxel-incorporating micellar nanoparticle formulation.

Production Methods

4-Phenylbutanol can be produced 1) from Phenylacetaldehyde and Acetaldehyde by condensation, followed by hydrogenation and reduction of the unsaturated aldehyde. 2) from Phenylethyl magnesiumbromide plus Ethylene oxide in a Grignard type reaction.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 31, p. 2607, 1983 DOI: 10.1248/cpb.31.2607
Journal of the American Chemical Society, 73, p. 124, 1951 DOI: 10.1021/ja01145a045

General Description

4-Phenyl-1-butanol is oxidized by ceric ammonium nitrate in acetonitrile to afford 2-phenyltetrahydrofuran. It undergoes cyclization in presence of phosphoric acid at high temperature to yield tetralin.

4-Phenylbutanol(3360-41-6)Related Product Information

• TRANS-2-PHENYL-1-CYCLOPROPANECARBOXYLIC ACID
• 3-BENZOYLPROPIONIC ACID
• 4-(4-Methoxyphenyl)butyric acid
• 3-(4-Chlorobenzoyl)propionic acid
• Oxytetracycline dihydrate
• GAMMA-PHENYL-GAMMA-BUTYROLACTONE
• 1,2,3,4-TETRAHYDRO-2-NAPHTHOIC ACID
• 4,5-Dihydro-5-(4-fluorophenyl)-2(3H)-furanone
• 2-PHENYLGLUTARIC ANHYDRIDE
• Diphenolic acid
• CYTOCHALASIN E
• 4-Phenylbutanol
• 4-(4-Nitrophenyl)butyric acid
• CYTOCHALASIN A
• Sodium 4-phenylbutyrate
• STRYCHNINE
• 10,11-Dimethoxystrychnine
• Trolox