4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Basic information
- Product Name:
- 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
- Synonyms:
-
- YM 976
- 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
- 4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one
- Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-
- YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory activities,antigen-induced airway responses,Inhibitor,YM976,YM 976
- CAS:
- 191219-80-4
- MF:
- C17H16ClN3O
- MW:
- 313.78
- Product Categories:
-
- Cyclic Nucleotide related
- Mol File:
- 191219-80-4.mol
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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Chemical Properties
- Melting point:
- 132.7-134.0 °C(lit.)
- Boiling point:
- 485.4±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: 16 mg/mL
- form
- solid
- pka
- 2.11±0.20(Predicted)
- color
- pale yellow
MSDS
- Language:English Provider:SigmaAldrich
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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Usage And Synthesis
Uses
YM 976 is an inhibitor of PDE4.
Definition
ChEBI: 4-(3-chlorophenyl)-1,7-diethyl-2-pyrido[2,3-d]pyrimidinone is a member of pyrimidines.
Biological Activity
Orally active PDE4 inhibitor (IC 50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONESupplier
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