4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
- Product Name
- 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
- CAS No.
- 191219-80-4
- Chemical Name
- 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
- Synonyms
- YM 976;4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE;4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one;Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-;YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory activities,antigen-induced airway responses,Inhibitor,YM976,YM 976
- CBNumber
- CB5725034
- Molecular Formula
- C17H16ClN3O
- Formula Weight
- 313.78
- MOL File
- 191219-80-4.mol
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Property
- Melting point:
- 132.7-134.0 °C(lit.)
- Boiling point:
- 485.4±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: 16 mg/mL
- form
- solid
- pka
- 2.11±0.20(Predicted)
- color
- pale yellow
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y4877
- Product name
- YM 976
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $266
- Updated
- 2022/05/15
- Product number
- Y4877
- Product name
- YM 976
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $1060
- Updated
- 2022/05/15
- Product number
- 29529
- Product name
- YM 976
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29529
- Product name
- YM 976
- Packaging
- 50mg
- Price
- $684
- Updated
- 2024/03/01
- Product number
- 29529
- Product name
- YM 976
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Chemical Properties,Usage,Production
Uses
YM 976 is an inhibitor of PDE4.
Definition
ChEBI: 4-(3-chlorophenyl)-1,7-diethyl-2-pyrido[2,3-d]pyrimidinone is a member of pyrimidines.
Biological Activity
Orally active PDE4 inhibitor (IC 50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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