4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

Product Name: 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
CAS No.: 191219-80-4
Chemical Name: 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
Synonyms: YM 976;4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE;4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one;Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-;YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory activities,antigen-induced airway responses,Inhibitor,YM976,YM 976
CBNumber: CB5725034
Molecular Formula: C17H16ClN3O
Formula Weight: 313.78
MOL File: 191219-80-4.mol

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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Property

Melting point:: 132.7-134.0 °C(lit.)
Boiling point:: 485.4±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: 16 mg/mL
form: solid
pka: 2.11±0.20(Predicted)
color: pale yellow

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y4877
Product name: YM 976
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $266
Updated: 2022/05/15

Sigma-Aldrich

Product number: Y4877
Product name: YM 976
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $1060
Updated: 2022/05/15

Cayman Chemical

Product number: 29529
Product name: YM 976
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29529
Product name: YM 976
Packaging: 50mg
Price: $684
Updated: 2024/03/01

Cayman Chemical

Product number: 29529
Product name: YM 976
Packaging: 10mg
Price: $166
Updated: 2024/03/01

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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Chemical Properties,Usage,Production

Uses

YM 976 is an inhibitor of PDE4.

Definition

ChEBI: 4-(3-chlorophenyl)-1,7-diethyl-2-pyrido[2,3-d]pyrimidinone is a member of pyrimidines.

Biological Activity

Orally active PDE4 inhibitor (IC 50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.

4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Suppliers

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191219-80-4, 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONERelated Search:

2-AMINO-3-ETHYL-6-METHYLPYRIDINE 2,5-DIMETHYL-PYRIDINEFORMAMIDE 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

YM 976

4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one

Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-

YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory activities,antigen-induced airway responses,Inhibitor,YM976,YM 976

191219-80-4

C17H16N3OCl

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Phosphodiesterase Inhibitors

Cyclic Nucleotide Metabolism

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide related