ChemicalBook > CAS DataBase List > 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

Product Name
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
CAS No.
191219-80-4
Chemical Name
4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
Synonyms
YM 976;4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE;4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one;Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-;YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory activities,antigen-induced airway responses,Inhibitor,YM976,YM 976
CBNumber
CB5725034
Molecular Formula
C17H16ClN3O
Formula Weight
313.78
MOL File
191219-80-4.mol
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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Property

Melting point:
132.7-134.0 °C(lit.)
Boiling point:
485.4±55.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: 16 mg/mL
form 
solid
pka
2.11±0.20(Predicted)
color 
pale yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y4877
Product name
YM 976
Purity
≥98% (HPLC)
Packaging
10mg
Price
$266
Updated
2022/05/15
Sigma-Aldrich
Product number
Y4877
Product name
YM 976
Purity
≥98% (HPLC)
Packaging
50mg
Price
$1060
Updated
2022/05/15
Cayman Chemical
Product number
29529
Product name
YM 976
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29529
Product name
YM 976
Packaging
50mg
Price
$684
Updated
2024/03/01
Cayman Chemical
Product number
29529
Product name
YM 976
Packaging
10mg
Price
$166
Updated
2024/03/01
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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Chemical Properties,Usage,Production

Uses

YM 976 is an inhibitor of PDE4.

Definition

ChEBI: 4-(3-chlorophenyl)-1,7-diethyl-2-pyrido[2,3-d]pyrimidinone is a member of pyrimidines.

Biological Activity

Orally active PDE4 inhibitor (IC 50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.

4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE Suppliers

China 29 Germany 2 Switzerland 1 United Kingdom 1 United States 9 USA 1 Global 43

191219-80-4, 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONERelated Search:

2-AMINO-3-ETHYL-6-METHYLPYRIDINE 2,5-DIMETHYL-PYRIDINEFORMAMIDE 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

  • YM 976
  • 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
  • 4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one
  • Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-
  • YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory activities,antigen-induced airway responses,Inhibitor,YM976,YM 976
  • 191219-80-4
  • C17H16N3OCl
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Phosphodiesterase Inhibitors
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Cyclic Nucleotide related