Basic information Safety Supplier Related

F16

Basic information Safety Supplier Related

F16 Basic information

Product Name:
F16
Synonyms:
  • F16
  • 4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
  • 4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE
  • F-16;COMPOUND F16
  • Compound F16)
  • F16 (F-16
  • 3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
  • F16/Cell proliferation inhibitor (F16)
CAS:
36098-33-6
MF:
C16H15IN2
MW:
362.21
Mol File:
36098-33-6.mol
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F16 Chemical Properties

storage temp. 
Store at -20°C
solubility 
≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
form 
Orange solid.
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F16 Usage And Synthesis

Uses

F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines.

Biological Activity

f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2].

References

[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336.

F16Supplier

Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Email
info@yuhaochemical.com
Wuhan Greatwall chemical Co,.LTD
Tel
400-027-6116 18086000087
Email
sales@chemgreatwall.com
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Email
chaolaichem@foxmail.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
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F16(36098-33-6)Related Product Information