H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 Basic information
- Product Name:
- H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
- Synonyms:
-
- H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
- MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (109-121) (HUMAN)
- METASTIN (42-54) (HUMAN)
- KISSPEPTIN-54 (42-54) (HUMAN)
- KISSPEPTIN-13
- KISSPEPTIN-13 (HUMAN)
- KISSPEPTIN-14 (2-14) (HUMAN)
- KISS-1 (109-121) (HUMAN)
- CAS:
- 374675-18-0
- MF:
- C78H107N21O18
- MW:
- 1626.81
- Mol File:
- 374675-18-0.mol
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 Chemical Properties
- Sequence
- Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 Usage And Synthesis
Uses
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research[1][2][3][4].
in vivo
Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor[1].
| Animal Model: | Male Swiss mice with memory impairment induced by A-beta[1] |
| Dosage: | 2 μg/side |
| Administration: | Intracerebroventricular administration; 2 μg/side; once |
| Result: | Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54. |
References
[1] Jiang JH, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 Sep;123:187-95. DOI:10.1016/j.nlm.2015.05.010
[2] Silvestre RA, et al., Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol. 2008 Feb;196(2):283-90. DOI:10.1677/JOE-07-0454
[3] Csabafi K, et al., Effects of kisspeptin-13 on the hypothalamic-pituitary-adrenal axis, thermoregulation, anxiety and locomotor activity in rats. Behav Brain Res. 2013 Mar 15;241:56-61. DOI:10.1016/j.bbr.2012.11.039
[4] Tanaka M, et al., Neurotransmissions of antidepressant-like effects of kisspeptin-13. Regul Pept. 2013 Jan 10;180:1-4. DOI:10.1016/j.regpep.2012.08.017
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2Supplier
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 0551-65326643 18156095617
- info@cellmano.com
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com