Basic information Safety Supplier Related

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER

Basic information Safety Supplier Related

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Basic information

Product Name:
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
Synonyms:
  • GGTI-2147
  • 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
  • TUQRZGWNDBXSNP-SANMLTNESA-N
  • GGTI-2147 (GGTI2147)
  • L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
  • Geranylgeranyl transferase inhibitor-2147
CAS:
191102-87-1
MF:
C28H30N4O3
MW:
470.56
Product Categories:
  • A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
  • Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Inhibitors
  • Other enzyme inhibitors and activators
Mol File:
Mol File
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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Chemical Properties

Boiling point:
710.6±60.0 °C(Predicted)
Density 
1.224±0.06 g/cm3(Predicted)
solubility 
Soluble in DMSO
pka
13.22±0.46(Predicted)
form 
Solid
Sensitive 
Light Sensitive & Hygroscopic
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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Usage And Synthesis

Uses

GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTERSupplier

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