4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Basic information
- Product Name:
- 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
- Synonyms:
-
- GGTI-2147
- 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
- TUQRZGWNDBXSNP-SANMLTNESA-N
- GGTI-2147 (GGTI2147)
- L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
- Geranylgeranyl transferase inhibitor-2147
- CAS:
- 191102-87-1
- MF:
- C28H30N4O3
- MW:
- 470.56
- Product Categories:
-
- A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
- Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Inhibitors
- Other enzyme inhibitors and activators
- Mol File:
- Mol File
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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Chemical Properties
- Boiling point:
- 710.6±60.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO
- pka
- 13.22±0.46(Predicted)
- form
- Solid
- Sensitive
- Light Sensitive & Hygroscopic
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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Usage And Synthesis
Uses
GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTERSupplier
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