ChemicalBook > CAS DataBase List > 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER

Product Name
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
CAS No.
191102-87-1
Chemical Name
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
Synonyms
GGTI-2147;GGTI-2147 (GGTI2147);TUQRZGWNDBXSNP-SANMLTNESA-N;Geranylgeranyl transferase inhibitor-2147;4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER;L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
CBNumber
CB5766770
Molecular Formula
C28H30N4O3
Formula Weight
470.56
MOL File
Mol file
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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Property

Boiling point:
710.6±60.0 °C(Predicted)
Density 
1.224±0.06 g/cm3(Predicted)
solubility 
Soluble in DMSO
pka
13.22±0.46(Predicted)
form 
Solid
Sensitive 
Light Sensitive & Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
345885
Product name
GGTI-2147 - CAS 191102-87-1 - Calbiochem
Purity
A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
Packaging
250μG
Price
$245
Updated
2024/03/01
Alfa Aesar
Product number
J65022
Product name
GGTI-2147
Packaging
100microg
Price
$591
Updated
2021/12/16
TRC
Product number
G368900
Product name
GGTI-2147
Packaging
5mg
Price
$1470
Updated
2021/12/16
TRC
Product number
G368900
Product name
GGTI-2147
Packaging
0.1mg
Price
$115
Updated
2021/12/16
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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Chemical Properties,Usage,Production

Uses

GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
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China
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VDM Biochemicals
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China
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Energy Chemical
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191102-87-1, 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTERRelated Search:


  • GGTI-2147
  • 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
  • TUQRZGWNDBXSNP-SANMLTNESA-N
  • GGTI-2147 (GGTI2147)
  • L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
  • Geranylgeranyl transferase inhibitor-2147
  • 191102-87-1
  • A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
  • Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Inhibitors
  • Other enzyme inhibitors and activators