4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE Chemical Properties

Boiling point:

105-106°C 1mm

Density 

1.260±0.06 g/cm3(Predicted)

refractive index 

1.5155

storage temp. 

Inert atmosphere,2-8°C

form 

liquid

color 

Clear, light orange

Sensitive 

Air Sensitive

InChI

InChI=1S/C9H8F2O3/c1-13-8-4-6(5-12)2-3-7(8)14-9(10)11/h2-5,9H,1H3

InChIKey

KGPOVKAYCXTCQS-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(OC(F)F)C(OC)=C1

CAS DataBase Reference

162401-70-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2913000090

4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE Usage And Synthesis

Synthesis

1. DMF (450 mL), vanillin (30.0 g, 0.2 mol) and sodium hydroxide (13.0 g, 0.325 mol) were added to a reaction flask. 2. The reaction system was warmed to 90 °C with continuous stirring for 2 hours. 3. Monochlorodifluoromethane gas was introduced into the reaction system and the reaction progress was monitored by TLC until the vanillin was completely consumed. 4. Upon completion of the reaction, the heating was stopped and the reaction system was cooled to room temperature. 5. The reaction was quenched by addition of water (450 mL) and the reaction mixture was extracted with dichloromethane. 6. The organic phase was washed sequentially with saturated sodium carbonate solution and saturated brine, then dried over anhydrous sodium sulfate. 7. Concentrate the organic phase under pressure to obtain a light yellow oil 3-methoxy-4-(difluoromethoxy)benzaldehyde (31.9 g, 80% yield, 99.2% purity, HPLC chromatogram in Fig. 1), which can be used in subsequent steps without further purification.

References

[1] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 727 - 730
[2] Patent: CN106883118, 2017, A. Location in patent: Paragraph 0038-0042

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