5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL Chemical Properties

Melting point:

53-57°C

Boiling point:

268℃

Density 

1.103

Flash point:

116℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

solid

pka

4.62±0.20(Predicted)

Appearance

Pale purple to purple Powder

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

WGK Germany 

3

HS Code 

2933399990

5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-amino-6-methoxy-5-methylpyridine from 2-methoxy-5-nitro-3-methylpyridine: (1c) 6-methoxy-5-methyl-3-pyridinamine [Eq. 10]; 2-methoxy-3-methyl-5-nitro-pyridine (1.63 g, 9.71 mmol) was dissolved in methanol (50 mL), 10% Pd/C catalyst was added (50% water content, 800 mg) and the reaction was stirred under hydrogen atmosphere for 2 h 10 min. Upon completion of the reaction, it was filtered through diatomaceous earth and the solvent was evaporated to afford 3-amino-6-methoxy-5-methylpyridine (1.25 g, 9.0 mmol, 93% yield) as a blue oil.1H NMR (400 MHz, DMSO-d6) δ ppm: 2.03 (3H, s), 3.73 (3H, s), 4.62 (2H, s), and 6.83-6.86 (1H, m), 7.31-7.34 (1H, m).

References

[1] Patent: WO2005/103049, 2005, A1. Location in patent: Page/Page column 63-64
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3056 - 3062

5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL(867012-70-2)Related Product Information

• 2-Methoxy-5-nitro-3-picoline
• 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE
• 3-BROMO-2-METHOXY-6-PICOLINE
• 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE
• 5-AMINO-3-BROMO-2-METHOXYPYRIDINE
• 2-Methoxy-3-nitropyridine
• 5-BROMO-2-METHOXY-3-NITRO-PYRIDINE
• 2-Methoxy-3-fluoro-5-bromopyridine
• 6-Chloro-2-methoxy-3-nitropyridine
• 2-METHOXY-3,5-DIBROMO-PYRIDINE
• 2-Methoxy-3-(trifluoromethyl)pyridine
• 5-BROMO-2-METHOXY-3-CYANOPYRIDINE
• 3-Iodo-2-methoxypyridine
• 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL
• 2,6-Dimethoxy-5-nitropyridine-3-carboxylic Acid
• 2-METHOXY-5-NITRO-NICOTINIC ACID
• 6-METHOXY-3-NITRO-5-PHENYL-PYRIDIN-2-YLAMINE
• 6-METHOXY-5-METHYLPYRIDINE-2,3-DIAMINE