1,1-Dichloro-2,2,2-trifluoroethane Chemical Properties

Melting point:

-107°C

Boiling point:

27.6°C

Density 

1,475 g/cm³

vapor pressure 

93.456kPa at 25.62℃

refractive index 

1.3290

Flash point:

9℃

storage temp. 

2-8°C

form 

A liquid

Water Solubility 

2.1g/L at 25℃

LogP

2.17 at 20℃

CAS DataBase Reference

306-83-2(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, 2,2-dichloro-1,1,1-trifluoro-(306-83-2)

EPA Substance Registry System

HCFC-123 (306-83-2)

Safety Information

Hazard Codes 

T,Xi,N

Risk Statements 

23/24/25-39-39/23/24/25-59

Safety Statements 

36/37-45-59

RIDADR 

3163

WGK Germany 

1

Hazard Note 

Irritant

TSCA 

T

HazardClass 

IRRITANT, GAS, OZONE DEPLETER

Hazardous Substances Data

306-83-2(Hazardous Substances Data)

Toxicity

LD50 skin in rabbit: > 2gm/kg

MSDS

• Language:English Provider:Dichlorotrifluoroethane

1,1-Dichloro-2,2,2-trifluoroethane Usage And Synthesis

Chemical Properties

1,1-Dichloro-2,2,2-trifluoroethane has a light ethereal odor with poor warning properties.

Uses

HCFC 123 is an interim replacement for the CFCs and is scheduled for a production phase-out during the 2020s. Its main application is as a substitute for CFC 11 in centrifugal chillers used for air conditioning of large buildings. It is also used in smaller air-conditioning units, and may have applications in foam blowing, and firefighting and as a chemical intermediate.

General Description

Colorless nonflammable gas. Nearly odorless.

Reactivity Profile

1,1-Dichloro-2,2,2-trifluoroethane is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. They suffer oxidation with strong oxidizing agents and under extremes of temperature.

Health Hazard

HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) has evidenced significant human liver toxicity. A group of 17 workers suffered liver damage in a 1997 outbreak. They were involved in containerizing this liquid. HCFC-123 is chemically similar to halothane and has the same toxic metabolite. HCFC- 123 exposure also was implicated as the cause of liver disease in nine industrial workers who had repeated exposure because of a leaking airconditioning system in 1996; the refrigerant also contained HCFC-124. HCFC-124 and HCFC-125 are also structurally similar to halothane.

Flammability and Explosibility

Non flammable

Safety Profile

Suspected carcinogen. Moderately toxic by inhalation. When heated to decomposition it emits very toxic fumes of Fand Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and FLUORIDES.

Carcinogenicity

An inhalation toxicity/oncogenicity study was conducted with groups of 80 male and 80 female rats. This study was described earlier in this section. In addition to the effects on serum chemistry parameters and the retina, increases in benign tumors of the pancreas, testes, and liver were reported. As noted above, the survival in the HCFC 123–exposed animals was better than in the airexposed controls. These tumors tended to appear near the end of the study and generally were not considered to be the cause of death.

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