[2H7]-Ropivacaine Chemical Properties

form 

Solid

color 

White to off-white

[2H7]-Ropivacaine Usage And Synthesis

Uses

Ropivacaine-d7 is deuterium labeled Ropivacaine. Ropivacain is a potent?sodium channel?blocker. Ropivacain blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain?management[1].

Definition

ChEBI: Ropivacaine is the piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline.

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. DOI:10.2165/00003495-200565180-00013
[3] Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. DOI:10.1371/journal.pone.0117321
[4] Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth DOI:10.1007/s00540-013-1661-1
[5] Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28. DOI:10.1016/j.lfs.2019.02.053

[2H7]-Ropivacaine(684647-62-9)Related Product Information

• Amlexanox
• 2-AMINO-7-ISOPROPYL-5-OXO-5 H-[1]BENZOPYRANO[2,3-B]PYRIDINE-3-CARBONITRILE
• Ethyl 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate
• Ropivacaine
• 5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, 2-amino-7-(1-hydroxy-1-methylethyl)-5-oxo-
• (±)-Ropivacaine-d7 (propyl-d7)
• ethyl 2-amino-7-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylate
• 5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, 7-acetyl-2-amino-5-oxo-