Rezvilutamide Chemical Properties

Boiling point:

648.3±65.0 °C(Predicted)

Density 

1.50±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 100 mg/mL (208.56 mM; Need ultrasonic)

pka

13.42±0.20(Predicted)

form 

Solid

color 

White to off-white

Rezvilutamide Usage And Synthesis

Uses

Rezvilutamide (SHR3680) is an orally active androgen receptor antagonist. Rezvilutamide (SHR3680) is used for the study of prostate cancer[1][2].

References

[1] SangjunYoo, et al. New drugs in prostate cancer. Prostate International Volume 4, Issue 2, June 2016, Pages 37-42.
[2] Veronica Mollica, et al. Molecular Mechanisms Related to Hormone Inhibition Resistance in Prostate Cancer. Cells. 2019 Jan 11;8(1):43. DOI:10.3390/cells8010043
[3] Dai T, et al., A single-centre, open-label, single-arm, fixed-sequence pharmacokinetic study of SHR3680 on repaglinide and bupropion in prostate cancer patients. Br J Clin Pharmacol. 2023 Feb;89(2):874-886. DOI:10.1111/bcp.15528