RS 504393 Chemical Properties

Density 

1.28

storage temp. 

2-8°C

solubility 

DMSO: soluble1mg/mL, clear (warmed)

form 

powder

color 

white to beige

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

RS 504393 Usage And Synthesis

Uses

RS 504393 is a small molecule antagonist at the CC chemokine receptor 2.

Uses

RS504393 has been used in mass spectrometry.

Definition

ChEBI: 6-methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-2-spiro[1H-3,1-benzoxazine-4,4'-piperidine]one is a member of 1,3-oxazoles.

Biological Activity

Extremely selective CCR2 chemokine receptor antagonist (IC 50 values are 98 nM and > 100 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC 50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Biochem/physiol Actions

RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys.

storage

Store at +4°C

RS 504393(300816-15-3)Related Product Information

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• RS 504393
• SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE