Tipelukast
Tipelukast Basic information
- Product Name:
- Tipelukast
- Synonyms:
-
- tipelukast
- KCA 757
- MN 001 (pharMaceutical)
- MN-001 (Tipelukast)
- 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)sulfanyl]propoxy]-2-propylphenoxy]butanoic acid
- Butanoic acid, 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-
- CAS:
- 125961-82-2
- MF:
- C29H38O7S
- MW:
- 530.67282
- Mol File:
- 125961-82-2.mol
Tipelukast Chemical Properties
- Melting point:
- 82-84°C
- Boiling point:
- 735.3±60.0 °C(Predicted)
- Density
- 1.22
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 4.59±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Beige
Tipelukast Usage And Synthesis
Uses
Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.
Definition
ChEBI: Tipelukast is an aromatic ketone.
Biological Activity
Tipelukast is a Leukotriene D4 (LTD4) receptor antagonist and an inhibitor of 5-lipoxygenase (5-LO) and also phosphodiesterases PDE3 and PDE4. It has been found to have antifibrotic and anti-inflammatory activity. Tipelukast has been investigated as a possible treatment for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
in vivo
Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs[2].
IC 50
LTD4: 6.41 (pA2, In guinea-pigs); LTE4: 6.45 (pA2, In guinea-pigs)
TipelukastSupplier
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- 1-(800)-881-8210
- inquiries@lgmpharma.com
- Tel
- 16314854226
- info@bocsci.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- 15911056312
- liming@bio-fount.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Tipelukast(125961-82-2)Related Product Information
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