nitrofurantoin sodium
nitrofurantoin sodium Basic information
- Product Name:
- nitrofurantoin sodium
- Synonyms:
-
- nitrofurantoin sodium
- 1-[(5-nitrofurfurylidene)amino]imidazolidine-2,4-dione, sodium salt
- NITROFURANTOIN, SODIUM SALT
- 1-[[(5-Nitro-2-furanyl)methylene]amino]-2-sodiooxyimidazolidin-4-one
- 1-[[(5-Nitro-2-furanyl)methylene]amino]-2-sodiooxyimidazolidine-4-one
- Ivadantin
- 2,4-Imidazolidinedione, 1-(((5-nitro-2-furanyl)methylene)amino)-, sodium salt (9ci)
- Einecs 200-216-7
- CAS:
- 54-87-5
- MF:
- C8H7N4NaO5
- MW:
- 262.16
- EINECS:
- 2002167
- Mol File:
- 54-87-5.mol
nitrofurantoin sodium Usage And Synthesis
Uses
Nitrofurantoin sodium is a potent and orally active antibacterial agent. Nitrofurantoin sodium acts as an antibiotic. Nitrofurantoin sodium can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1][2].
brand name
Ivadantin (Procter & Gamble).
in vivo
| Parameters | 10 mg/kg p.o. | 2 mg/kg i.v. |
| AUC0-720 (μg/mL?min) | 306 | |
| AUC0-120 (μg/mL?min) | 90.3 | |
| AUC0-∞ (μg/mL?min) | 344 | 91.5 |
| Cmax (μg/mL) | 1.01 | |
| CL/F or CL (ml/min/kg) | 31.0 | 22.7 |
| t1/2 (min) | 166 | 23.6 |
| Bioavailability (%) | 60.1 | |
References
[1] Huttner A, et al. Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials. J Antimicrob Chemother. 2015 Sep;70(9):2456-64. DOI:10.1093/jac/dkv147
[2] Garau J. Other antimicrobials of interest in the era of extended-spectrum beta-lactamases: fosfomycin, nitrofurantoin and tigecycline. Clin Microbiol Infect. 2008 Jan;14 Suppl 1:198-202. DOI:10.1111/j.1469-0691.2007.01852.x
[3] Linus Sandegren, et al. Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli. J Antimicrob Chemother. 2008 Sep;62(3):495-503. DOI:10.1093/jac/dkn222
[4] Xiaodong Wang, et al. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos. 2007 Feb;35(2):268-74. DOI:10.1124/dmd.106.011684
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