Pyrrobutamine phosphate CAS#: 135-31-9

Pyrrobutamine phosphate Basic information

Product Name:

Pyrrobutamine phosphate

Synonyms:

1-(4-(4-chlorophenyl)-3-phenylbut-2-enyl)pyrrolidine pentahydrogen bis(phosphate)
1-(4-(p-Chlorophenyl)-3-phenyl-2-butenyl)pyrrolidine diphosphate
1-(gamma-(p-Chlorobenzyl)cinnamyl)pyrrolidine diphosphate
1-p-Chlorophenyl-2-phenyl-4-pyrrolidyl-2-butene diphosphate
Einecs 205-185-3
Pyrrobutamine diphosphate
Pyrrobutamine phosphate

CAS:

135-31-9

MF:

C20H28ClNO8P2

MW:

507.838742

EINECS:

205-185-3

Mol File:

135-31-9.mol

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Pyrrobutamine phosphate Chemical Properties

Melting point:: 129.5-130°
pka: pKa1 8.77, pka2 5.23(at 25℃)

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Safety Information

Toxicity: LD50 in mice, guinea pigs (mg/kg): 1270 ±156, 1241 ±165 s.c.; 836.8 ±95, 625.6 ±41.9 i.m.; 1116 ±73, 992.6 ±107 orally; in mice (mg/kg): 53.53 ±1.61 i.v. (Lee)

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Pyrrobutamine phosphate Usage And Synthesis

Chemical Properties

Cream to off-white powder; slight odor; bitter taste. Melting range 127–131C. Soluble in water; slightly soluble in alcohol; almost insoluble in chloroform and ether.

Uses

Medicine (antihistamine).

brand name

Pyronil (Lilly).

General Description

Pyrrobutamine phosphate,(E)-1-[4-(4-chlorophenyl)-3-phenyl-2-butenyl]pyrrolidinediphosphate (Pyronil), is a white crystalline powder that issoluble to the extent of 10% in warm water. Pyrrobutaminewas investigated originally as the hydrochloride salt, but thediphosphate was absorbed more readily and completely.Clinical studies indicate that it is long acting, with a comparativelyslow onset of action. The weak antihistaminic propertiesof several analogs point to the importance of having aplanar ArC=CH-CH₂N unit and a pyrrolidino group as theside chain tertiary amine.