Serdexmethylphenidate
Serdexmethylphenidate Basic information
- Product Name:
- Serdexmethylphenidate
- Synonyms:
-
- Serdexmethylphenidate
- CAS:
- 1996626-29-9
- MF:
- C25H29N3O8
- MW:
- 499.52
- Mol File:
- 1996626-29-9.mol
Serdexmethylphenidate Usage And Synthesis
Uses
Serdexmethylphenidate is part of the composition of Azstarys, which consists of a prodrug/drug co-formulation ofserdexmethylphenidate and dexmethylphenidate in a 70:30 molar ratio. Azstarys is approved by the USFDA for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years of age and older. Serdexmethylphenidate consists of pharmacologically active dimethylphenidate attached to the nicotinoyl-L-serine portion via a carboxymethylene linker.
Metabolism
Catabolism of serdexmethylphenidate is believed to occur in the lower gastrointestinal tract. As a result, therapeutic doses of the released dexmethylphenidate do not generally appear until several hours after ingestion. As such, the long-duration action of this prodrug is combined with immediate-release dexmethylphenidate in the marketed combination therapy.