Basic information Safety Supplier Related

azafenidin

Basic information Safety Supplier Related

azafenidin Basic information

Product Name:
azafenidin
Synonyms:
  • 2-(2,4-dichloro-5-prop-2-ynyloxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazole(4,3-a)pyridin-3(2H)-one
  • azafenidin
  • Evolus
  • Milestone
  • 2-(2,4-dichloro-5-prop-2-ynyloxypnenyl)-5,6,7,8-tetrahy-dro-1,2,4-trizolo [4,3-α] pyridin-3-(2H)-one
  • DPX-R 6447
  • IN-R 6447
  • R 6447
CAS:
68049-83-2
MF:
C15H13Cl2N3O2
MW:
338.19
Product Categories:
  • Agro-Products, Aromatics, Heterocycles
Mol File:
68049-83-2.mol
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azafenidin Chemical Properties

Melting point:
168-168.5°
Boiling point:
468.9±55.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.45±0.20(Predicted)
color 
Brown to Dark Brown
EPA Substance Registry System
Azafeniden (68049-83-2)
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Safety Information

Hazard Codes 
T,N
Risk Statements 
61-48/22-62-50/53
Safety Statements 
53-45-60-61
Toxicity
LD50 in rats, mice, bobwhite quail, mallard duck (mg/kg): >5000, >5000, >2500, >2500 orally; in rabbits (mg/kg): >2000 dermally.; LC50 in rats, rainbow trout, blue gill sunfish (mg/l): >5.3, 33, 48 (Amuti)
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azafenidin Usage And Synthesis

Uses

Azafenidin is a weed controlling herbicide used in various crops.

Uses

Herbicide.

Definition

ChEBI: Azafenidin is a triazolopyridine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one which is substituted at position 2 by a 2,4-dichloro-5-(prop-2-yn-1-yloxy)phenyl group. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control weeds in fruit crops such as pineapple, citrus, melons, and grapes. Not approved for use within the European Union. It has a role as an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor. It is a triazolopyridine, a terminal acetylenic compound and a dichlorobenzene.

Metabolic pathway

A common degradation reaction of azafenidin in light, plants and soil is O-dealkylation, and interesting minor reactions in soil are the subsequent methylation of the O-dealkylated degradation product and the reduction of the propynyl group under anaerobic conditions. In soil and light, azafenidin is also readily split to form the triazolinone heterocycle. Azafenidin is readily metabolized in rats and lactating goats through O-dealkylation, hydroxylation of the triazolinone ring in several positions, and glucuronide and sulfate conjugation.

azafenidin Preparation Products And Raw materials

Raw materials

azafenidinSupplier

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