Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and proteins >  Poly-L-lysine

Poly-L-lysine

Basic information Safety Supplier Related

Poly-L-lysine Basic information

Product Name:
Poly-L-lysine
Synonyms:
  • POLYLYSINE
  • POLYLYSINE, CPC PEPTIDE
  • LYS-LYS-LYS-LYS-LYS-LYS-LYS-LYS-LYS-LYS
  • Epsilon-Poly-L-Lysin
  • epsilon-Lysine homopolymer
  • Lysine homopolymer
  • Lysine polymer
  • Lysine homopolymer, L-
CAS:
25104-18-1
MF:
C6H14N2O2
MW:
146.19
EINECS:
219-078-4
Mol File:
25104-18-1.mol
More
Less

Poly-L-lysine Chemical Properties

storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
InChI
InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/s3
InChIKey
KDXKERNSBIXSRK-GQMHJJTINA-N
SMILES
[C@@H](N)(C(=O)O)CCCCN |&1:0,r|
More
Less

Poly-L-lysine Usage And Synthesis

Chemical Properties

Polylysine is a synthetic polymer that is used to promote pluripotency in cells. It has been shown to be effective when combined with l-lysine, which promotes cell transformation and cellular physiology. It has also been shown to inhibit the synthesis of ubiquitin ligases, which are enzymes involved in the degradation of proteins.

Uses

Polylysine can also be used as a chemical probe for cancer tissues due to its ability to bind to lysine residues on proteins, which are not present on normal tissue or healthy cells.

Production Methods

E-Polylysine is manufactured using an aerobic fermentation process using the non-toxic microorganism Streptomyces albulus. Raw materials and processing aids entering in the production of Epsilon-polylysine are all food-grade quality.

Definition

ChEBI: L-lysine is an L-alpha-amino acid; the L-isomer of lysine. It has a role as a micronutrient, a nutraceutical, an anticonvulsant, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is an aspartate family amino acid, a proteinogenic amino acid, a lysine and a L-alpha-amino acid. It is a conjugate base of a L-lysinium(1+). It is a conjugate acid of a L-lysinate. It is an enantiomer of a D-lysine. It is a tautomer of a L-lysine zwitterion.

Application

Poly-L-Lysine is a synthetic amino acid chain that is positively charged and widely used as a coating substrate for culture dishes, slides, etc, to enhance cell attachment and adhesion to plasticware and glass surfaces. This product’s molecular weight ranges from 70,000 to 150,000 Da. It can be used in conjugation to methotrexate for increased drug transport. For Microencapsulation of islets. It is also used in simple, reproducible procedures for chromosomal preparations from various tissues. For immobilation of living cells in biocompatible semipermeable microcapsules. In the preparation of polycationic beads. Conjugation to albumin and horseradish peroxidase to enhance cellular uptake. Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.

Biological Activity

Polylysine (Poly-L-lysine) itself is not inert and may influence many cellular processes: Polylysine can exert selective toxicity towards some tumour cells; it can activate phospholipases and, thus, may affect membrane permeability; it increases cell division in Friend erythroleukemia and two mouse lymphoma cell lines; polylysine has been shown to activate a microtubule-associated protein 2 kinase in vitro; polylysine can exert a lytic activity against several membranes and cells. Bashford et al. have shown that polylysine leads to the efflux of small ions and a change in the membrane potential of Lettre cells. On the other hand, polylysine (in contrast to lipophilic polylysine) did not release the internal contents of either liposomes or erythrocytes.

Poly-L-lysineSupplier

Shandong Yatu Biotechnology Co. LTD Gold
Tel
0531-55555418 15301096991
Email
811301959@qq.com
Zhengzhou Yuhe Food Additive Co. LTD Gold
Tel
0371-56060979 13838386843
Email
2922109373@qq.com
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Email
sales.bj@hwrkchemical.com
Energy Chemical
Tel
021-021-58432009 400-005-6266
Email
sales8178@energy-chemical.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com